| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| creA | glyA-I | PP_3667 | PP_0322 | Creatinase; Function experimentally demonstrated in the studied species; enzyme; Proteinfate : Degradation of proteins, peptides, and glycopeptides. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.452 |
| creA | glyA-II | PP_3667 | PP_0671 | Creatinase; Function experimentally demonstrated in the studied species; enzyme; Proteinfate : Degradation of proteins, peptides, and glycopeptides. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.402 |
| creA | soxA | PP_3667 | PP_0325 | Creatinase; Function experimentally demonstrated in the studied species; enzyme; Proteinfate : Degradation of proteins, peptides, and glycopeptides. | Sarcosine oxidase subunit alpha; Function experimentally demonstrated in the studied genus; enzyme; Fattyacidandphospholipidmetabolism : Degradation; Belongs to the GcvT family. | 0.966 |
| creA | soxB | PP_3667 | PP_0323 | Creatinase; Function experimentally demonstrated in the studied species; enzyme; Proteinfate : Degradation of proteins, peptides, and glycopeptides. | Sarcosine oxidase subunit beta; Function experimentally demonstrated in the studied genus; enzyme; Fattyacidandphospholipidmetabolism : Degradation. | 0.956 |
| creA | soxD | PP_3667 | PP_0324 | Creatinase; Function experimentally demonstrated in the studied species; enzyme; Proteinfate : Degradation of proteins, peptides, and glycopeptides. | Sarcosine oxidase subunit delta; Function experimentally demonstrated in the studied genus; enzyme; Fattyacidandphospholipidmetabolism : Degradation. | 0.956 |
| creA | soxG | PP_3667 | PP_0326 | Creatinase; Function experimentally demonstrated in the studied species; enzyme; Proteinfate : Degradation of proteins, peptides, and glycopeptides. | Sarcosine oxidase subunit gamma; Function experimentally demonstrated in the studied genus; enzyme; Fattyacidandphospholipidmetabolism : Degradation. | 0.950 |
| gbcB | gcvP-I | PP_0316 | PP_0988 | Putative glycine-betaine dioxygenase subunit; Function experimentally demonstrated in the studied genus; putative enzyme; Fattyacidandphospholipidmetabolism : Degradation. | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein (By similarity); Belongs to the GcvP family. | 0.752 |
| gbcB | gcvP-II | PP_0316 | PP_5192 | Putative glycine-betaine dioxygenase subunit; Function experimentally demonstrated in the studied genus; putative enzyme; Fattyacidandphospholipidmetabolism : Degradation. | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein (By similarity); Belongs to the GcvP family. | 0.648 |
| gbcB | glyA-I | PP_0316 | PP_0322 | Putative glycine-betaine dioxygenase subunit; Function experimentally demonstrated in the studied genus; putative enzyme; Fattyacidandphospholipidmetabolism : Degradation. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.470 |
| gbcB | glyA-II | PP_0316 | PP_0671 | Putative glycine-betaine dioxygenase subunit; Function experimentally demonstrated in the studied genus; putative enzyme; Fattyacidandphospholipidmetabolism : Degradation. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.735 |
| gbcB | soxA | PP_0316 | PP_0325 | Putative glycine-betaine dioxygenase subunit; Function experimentally demonstrated in the studied genus; putative enzyme; Fattyacidandphospholipidmetabolism : Degradation. | Sarcosine oxidase subunit alpha; Function experimentally demonstrated in the studied genus; enzyme; Fattyacidandphospholipidmetabolism : Degradation; Belongs to the GcvT family. | 0.887 |
| gbcB | soxB | PP_0316 | PP_0323 | Putative glycine-betaine dioxygenase subunit; Function experimentally demonstrated in the studied genus; putative enzyme; Fattyacidandphospholipidmetabolism : Degradation. | Sarcosine oxidase subunit beta; Function experimentally demonstrated in the studied genus; enzyme; Fattyacidandphospholipidmetabolism : Degradation. | 0.722 |
| gbcB | soxD | PP_0316 | PP_0324 | Putative glycine-betaine dioxygenase subunit; Function experimentally demonstrated in the studied genus; putative enzyme; Fattyacidandphospholipidmetabolism : Degradation. | Sarcosine oxidase subunit delta; Function experimentally demonstrated in the studied genus; enzyme; Fattyacidandphospholipidmetabolism : Degradation. | 0.774 |
| gbcB | soxG | PP_0316 | PP_0326 | Putative glycine-betaine dioxygenase subunit; Function experimentally demonstrated in the studied genus; putative enzyme; Fattyacidandphospholipidmetabolism : Degradation. | Sarcosine oxidase subunit gamma; Function experimentally demonstrated in the studied genus; enzyme; Fattyacidandphospholipidmetabolism : Degradation. | 0.802 |
| gcvP-I | gbcB | PP_0988 | PP_0316 | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein (By similarity); Belongs to the GcvP family. | Putative glycine-betaine dioxygenase subunit; Function experimentally demonstrated in the studied genus; putative enzyme; Fattyacidandphospholipidmetabolism : Degradation. | 0.752 |
| gcvP-I | gcvP-II | PP_0988 | PP_5192 | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein (By similarity); Belongs to the GcvP family. | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein (By similarity); Belongs to the GcvP family. | 0.999 |
| gcvP-I | glyA-I | PP_0988 | PP_0322 | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein (By similarity); Belongs to the GcvP family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.990 |
| gcvP-I | glyA-II | PP_0988 | PP_0671 | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein (By similarity); Belongs to the GcvP family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.995 |
| gcvP-I | ltaE | PP_0988 | PP_0321 | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein (By similarity); Belongs to the GcvP family. | Low specificity L-threonine aldolase; Catalyzes the cleavage of L-allo-threonine and L-threonine to glycine and acetaldehyde. | 0.950 |
| gcvP-I | soxA | PP_0988 | PP_0325 | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein (By similarity); Belongs to the GcvP family. | Sarcosine oxidase subunit alpha; Function experimentally demonstrated in the studied genus; enzyme; Fattyacidandphospholipidmetabolism : Degradation; Belongs to the GcvT family. | 0.996 |