| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| crtZ | dxs | PP_3246 | PP_0527 | Beta-carotene hydroxylase. | 1-deoxyxylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. | 0.647 |
| crtZ | ispA | PP_3246 | PP_0528 | Beta-carotene hydroxylase. | Farnesyl diphosphate synthase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Biosynthesis of cofactors, prosthetic groups, and carriers; Belongs to the FPP/GGPP synthase family. | 0.874 |
| dxs | crtZ | PP_0527 | PP_3246 | 1-deoxyxylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. | Beta-carotene hydroxylase. | 0.647 |
| dxs | ispA | PP_0527 | PP_0528 | 1-deoxyxylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. | Farnesyl diphosphate synthase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Biosynthesis of cofactors, prosthetic groups, and carriers; Belongs to the FPP/GGPP synthase family. | 0.924 |
| dxs | ispH | PP_0527 | PP_0606 | 1-deoxyxylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. | 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Belongs to the IspH family. | 0.976 |
| dxs | thiL | PP_0527 | PP_0519 | 1-deoxyxylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. | Thiamin monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. | 0.532 |
| dxs | uppS | PP_0527 | PP_1595 | 1-deoxyxylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific); Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with (2E,6E)-farnesyl diphosphate (E,E-FPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E,38E)-undecaprenyl diphosphate (di- trans,octa-cis-UPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide. | 0.524 |
| dxs | xseB | PP_0527 | PP_0529 | 1-deoxyxylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. | Exodeoxyribonuclease 7 small subunit; Bidirectionally degrades single-stranded DNA into large acid- insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides; Belongs to the XseB family. | 0.643 |
| ispA | crtZ | PP_0528 | PP_3246 | Farnesyl diphosphate synthase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Biosynthesis of cofactors, prosthetic groups, and carriers; Belongs to the FPP/GGPP synthase family. | Beta-carotene hydroxylase. | 0.874 |
| ispA | dxs | PP_0528 | PP_0527 | Farnesyl diphosphate synthase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Biosynthesis of cofactors, prosthetic groups, and carriers; Belongs to the FPP/GGPP synthase family. | 1-deoxyxylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. | 0.924 |
| ispA | ispB | PP_0528 | PP_0687 | Farnesyl diphosphate synthase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Biosynthesis of cofactors, prosthetic groups, and carriers; Belongs to the FPP/GGPP synthase family. | Octaprenyl diphosphate synthase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Biosynthesis of cofactors, prosthetic groups, and carriers; Belongs to the FPP/GGPP synthase family. | 0.926 |
| ispA | ispH | PP_0528 | PP_0606 | Farnesyl diphosphate synthase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Biosynthesis of cofactors, prosthetic groups, and carriers; Belongs to the FPP/GGPP synthase family. | 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Belongs to the IspH family. | 0.947 |
| ispA | lldD | PP_0528 | PP_4736 | Farnesyl diphosphate synthase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Biosynthesis of cofactors, prosthetic groups, and carriers; Belongs to the FPP/GGPP synthase family. | L-lactate dehydrogenase; Catalyzes the conversion of L-lactate to pyruvate. Is coupled to the respiratory chain. | 0.649 |
| ispA | tadA | PP_0528 | PP_1035 | Farnesyl diphosphate synthase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Biosynthesis of cofactors, prosthetic groups, and carriers; Belongs to the FPP/GGPP synthase family. | tRNA-specific adenosine deaminase monomer; Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2); Belongs to the cytidine and deoxycytidylate deaminase family. | 0.618 |
| ispA | thiL | PP_0528 | PP_0519 | Farnesyl diphosphate synthase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Biosynthesis of cofactors, prosthetic groups, and carriers; Belongs to the FPP/GGPP synthase family. | Thiamin monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. | 0.590 |
| ispA | uppS | PP_0528 | PP_1595 | Farnesyl diphosphate synthase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Biosynthesis of cofactors, prosthetic groups, and carriers; Belongs to the FPP/GGPP synthase family. | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific); Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with (2E,6E)-farnesyl diphosphate (E,E-FPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E,38E)-undecaprenyl diphosphate (di- trans,octa-cis-UPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide. | 0.970 |
| ispA | xseA | PP_0528 | PP_1027 | Farnesyl diphosphate synthase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Biosynthesis of cofactors, prosthetic groups, and carriers; Belongs to the FPP/GGPP synthase family. | Exodeoxyribonuclease 7 large subunit; Bidirectionally degrades single-stranded DNA into large acid- insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides; Belongs to the XseA family. | 0.696 |
| ispA | xseB | PP_0528 | PP_0529 | Farnesyl diphosphate synthase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Biosynthesis of cofactors, prosthetic groups, and carriers; Belongs to the FPP/GGPP synthase family. | Exodeoxyribonuclease 7 small subunit; Bidirectionally degrades single-stranded DNA into large acid- insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides; Belongs to the XseB family. | 0.975 |
| ispB | ispA | PP_0687 | PP_0528 | Octaprenyl diphosphate synthase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Biosynthesis of cofactors, prosthetic groups, and carriers; Belongs to the FPP/GGPP synthase family. | Farnesyl diphosphate synthase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Biosynthesis of cofactors, prosthetic groups, and carriers; Belongs to the FPP/GGPP synthase family. | 0.926 |
| ispB | thiL | PP_0687 | PP_0519 | Octaprenyl diphosphate synthase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Biosynthesis of cofactors, prosthetic groups, and carriers; Belongs to the FPP/GGPP synthase family. | Thiamin monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. | 0.418 |