STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
thiOFAD-dependent glycine/D-amino acid oxidase; Catalyzes the oxidation of glycine, leading to glyoxyl imine and hydrogen peroxide as primary products; glyoxyl imine is used for the biosynthesis of the thiazole ring of thiamine. Otherwise, glyoxyl imine is spontaneously hydrolyzed in water to produce glyoxylate and ammonia. Can also use sarcosine (N-methylglycine) as substrate, and, to a lesser extent, N-ethylglycine and D-proline. Has no activity towards other amino-acids D-Asp, D-Glu, D-Gln, D-His, D-Leu, D-Lys, D- ornithine, D-Trp, D-Val, L-Ala, L-Asp, L-Glu, L-His, L-Leu, L-Lys, L- Met [...] (365 aa)    
Predicted Functional Partners:
thiG
Thiazole synthase; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.
 
 0.999
pilE
Type IV pili biogenesis protein PilE.
 
    0.858
thiD
Phosphomethylpyrimidine kinase.
 
  
 0.847
ooxA
Opine oxidase subunit A; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Energymetabolism : Amino acids and amines.
 
 
 0.751
soxA
Sarcosine oxidase subunit alpha; Function experimentally demonstrated in the studied genus; enzyme; Fattyacidandphospholipidmetabolism : Degradation; Belongs to the GcvT family.
  
 
 0.730
PP_0609
Homologs of previously reported genes of unknown function.
       0.663
PP_0610
Homologs of previously reported genes of unknown function.
       0.663
PP_0608
Putative type 4 fimbrial biogenesis protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative structure.
  
    0.635
PP_5105
Sulfur carrier protein ThiS.
 
  
 0.586
dadX
Alanine racemase, PLP-binding; Isomerizes L-alanine to D-alanine which is then likely oxidized to pyruvate by DadA. Shows racemase activity with both alanine stereoisomers, negligible activity with D-cysteine and L-serine, and exhibits no activity with the remaining natural chiral amino acids.
  
  
 0.497
Your Current Organism:
Pseudomonas putida KT2440
NCBI taxonomy Id: 160488
Other names: P. putida KT2440, Pseudomonas putida (strain KT2440), Pseudomonas putida str. KT2440
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