node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
PP_1944 | gcvH-I | PP_1944 | PP_0989 | Putative Aminomethyltransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Belongs to the GcvT family. | Glycine cleavage system H protein 1; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.983 |
PP_1944 | gcvH-II | PP_1944 | PP_5193 | Putative Aminomethyltransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Belongs to the GcvT family. | Glycine cleavage system H protein 2; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.975 |
PP_1944 | gcvP-I | PP_1944 | PP_0988 | Putative Aminomethyltransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Belongs to the GcvT family. | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein (By similarity); Belongs to the GcvP family. | 0.996 |
PP_1944 | gcvP-II | PP_1944 | PP_5192 | Putative Aminomethyltransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Belongs to the GcvT family. | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein (By similarity); Belongs to the GcvP family. | 0.995 |
PP_1944 | gcvT-I | PP_1944 | PP_0986 | Putative Aminomethyltransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Belongs to the GcvT family. | Aminomethyltransferase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Centralintermediarymetabolism : One-carbon metabolism. | 0.444 |
PP_1944 | gcvT-II | PP_1944 | PP_5194 | Putative Aminomethyltransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Belongs to the GcvT family. | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | 0.513 |
PP_1944 | glyA-I | PP_1944 | PP_0322 | Putative Aminomethyltransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Belongs to the GcvT family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.461 |
PP_1944 | glyA-II | PP_1944 | PP_0671 | Putative Aminomethyltransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Belongs to the GcvT family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.728 |
PP_1944 | soxA | PP_1944 | PP_0325 | Putative Aminomethyltransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Belongs to the GcvT family. | Sarcosine oxidase subunit alpha; Function experimentally demonstrated in the studied genus; enzyme; Fattyacidandphospholipidmetabolism : Degradation; Belongs to the GcvT family. | 0.675 |
gcvH-I | PP_1944 | PP_0989 | PP_1944 | Glycine cleavage system H protein 1; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Putative Aminomethyltransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Belongs to the GcvT family. | 0.983 |
gcvH-I | gcvH-II | PP_0989 | PP_5193 | Glycine cleavage system H protein 1; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Glycine cleavage system H protein 2; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.905 |
gcvH-I | gcvP-I | PP_0989 | PP_0988 | Glycine cleavage system H protein 1; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein (By similarity); Belongs to the GcvP family. | 0.999 |
gcvH-I | gcvP-II | PP_0989 | PP_5192 | Glycine cleavage system H protein 1; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein (By similarity); Belongs to the GcvP family. | 0.999 |
gcvH-I | gcvT-I | PP_0989 | PP_0986 | Glycine cleavage system H protein 1; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Aminomethyltransferase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Centralintermediarymetabolism : One-carbon metabolism. | 0.999 |
gcvH-I | gcvT-II | PP_0989 | PP_5194 | Glycine cleavage system H protein 1; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | 0.999 |
gcvH-I | glyA-I | PP_0989 | PP_0322 | Glycine cleavage system H protein 1; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.943 |
gcvH-I | glyA-II | PP_0989 | PP_0671 | Glycine cleavage system H protein 1; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.971 |
gcvH-I | soxA | PP_0989 | PP_0325 | Glycine cleavage system H protein 1; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Sarcosine oxidase subunit alpha; Function experimentally demonstrated in the studied genus; enzyme; Fattyacidandphospholipidmetabolism : Degradation; Belongs to the GcvT family. | 0.861 |
gcvH-II | PP_1944 | PP_5193 | PP_1944 | Glycine cleavage system H protein 2; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Putative Aminomethyltransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Belongs to the GcvT family. | 0.975 |
gcvH-II | gcvH-I | PP_5193 | PP_0989 | Glycine cleavage system H protein 2; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Glycine cleavage system H protein 1; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.905 |