| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ampC | gyrA | PP_2876 | PP_1767 | Beta-lactamase. | DNA gyrase, subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | 0.798 |
| ampC | mexT | PP_2876 | PP_2826 | Beta-lactamase. | Transcriptional regulator MexT; Belongs to the LysR transcriptional regulatory family. | 0.632 |
| ampC | oprD | PP_2876 | PP_1206 | Beta-lactamase. | Basic-amino-acid specific porin OprD; Function experimentally demonstrated in the studied genus; transporter; Transportandbindingproteins : Porins. | 0.819 |
| ampC | oprJ | PP_2876 | PP_2819 | Beta-lactamase. | Outer membrane protein OprJ. | 0.744 |
| ampC | oprN | PP_2876 | PP_3427 | Beta-lactamase. | Multidrug efflux RND outer membrane protein OprN. | 0.656 |
| ampC | parC | PP_2876 | PP_4912 | Beta-lactamase. | DNA topoisomerase IV subunit A; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule; Belongs to the type II topoisomerase GyrA/ParC subunit family. ParC type 1 subfamily. | 0.785 |
| gyrA | ampC | PP_1767 | PP_2876 | DNA gyrase, subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | Beta-lactamase. | 0.798 |
| gyrA | mexT | PP_1767 | PP_2826 | DNA gyrase, subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | Transcriptional regulator MexT; Belongs to the LysR transcriptional regulatory family. | 0.704 |
| gyrA | oprD | PP_1767 | PP_1206 | DNA gyrase, subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | Basic-amino-acid specific porin OprD; Function experimentally demonstrated in the studied genus; transporter; Transportandbindingproteins : Porins. | 0.741 |
| gyrA | oprJ | PP_1767 | PP_2819 | DNA gyrase, subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | Outer membrane protein OprJ. | 0.715 |
| gyrA | oprN | PP_1767 | PP_3427 | DNA gyrase, subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | Multidrug efflux RND outer membrane protein OprN. | 0.666 |
| gyrA | parC | PP_1767 | PP_4912 | DNA gyrase, subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | DNA topoisomerase IV subunit A; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule; Belongs to the type II topoisomerase GyrA/ParC subunit family. ParC type 1 subfamily. | 0.808 |
| mexT | ampC | PP_2826 | PP_2876 | Transcriptional regulator MexT; Belongs to the LysR transcriptional regulatory family. | Beta-lactamase. | 0.632 |
| mexT | gyrA | PP_2826 | PP_1767 | Transcriptional regulator MexT; Belongs to the LysR transcriptional regulatory family. | DNA gyrase, subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | 0.704 |
| mexT | oprD | PP_2826 | PP_1206 | Transcriptional regulator MexT; Belongs to the LysR transcriptional regulatory family. | Basic-amino-acid specific porin OprD; Function experimentally demonstrated in the studied genus; transporter; Transportandbindingproteins : Porins. | 0.766 |
| mexT | oprJ | PP_2826 | PP_2819 | Transcriptional regulator MexT; Belongs to the LysR transcriptional regulatory family. | Outer membrane protein OprJ. | 0.861 |
| mexT | oprN | PP_2826 | PP_3427 | Transcriptional regulator MexT; Belongs to the LysR transcriptional regulatory family. | Multidrug efflux RND outer membrane protein OprN. | 0.953 |
| mexT | parC | PP_2826 | PP_4912 | Transcriptional regulator MexT; Belongs to the LysR transcriptional regulatory family. | DNA topoisomerase IV subunit A; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule; Belongs to the type II topoisomerase GyrA/ParC subunit family. ParC type 1 subfamily. | 0.709 |
| oprC | oprD | PP_4838 | PP_1206 | Outer membrane copper receptor OprC. | Basic-amino-acid specific porin OprD; Function experimentally demonstrated in the studied genus; transporter; Transportandbindingproteins : Porins. | 0.843 |
| oprC | oprF | PP_4838 | PP_2089 | Outer membrane copper receptor OprC. | Outer membrane porin F. | 0.795 |