STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
prpA4-hydroxyproline epimerase; Catalyzes the reversible epimerization of cis-4-hydroxy-D- proline (c4DHyp) to trans-4-hydroxy-L-proline (t4LHyp). May be involved in a degradation pathway that allows P.putida strain KT2440 to grow on either epimer of 4-hydroxyproline, c4DHyp and t4LHyp, as the sole carbon and nitrogen source. Does not exhibit measureable racemase activity in vitro with any of the 19 natural chiral amino acid enantiomers. (308 aa)    
Predicted Functional Partners:
PP_1255
Putative cis-4-hydroxy-D-proline oxidase; No homology to any previously reported sequences; putative enzyme; Energymetabolism : Amino acids and amines.
 
 
 0.983
PP_1256
Putative alpha-ketoglutarate semialdehyde dehydrogenase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Energymetabolism : Amino acids and amines.
 
 
 0.959
PP_1257
Putative 1-pyrroline-4-hydroxy-2-carboxylate deaminase; No homology to any previously reported sequences; putative enzyme; Energymetabolism : Amino acids and amines; Belongs to the DapA family.
 
  
 0.917
proI
Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
    
 0.915
proS
Proline--tRNA ligase; Catalyzes the attachment of proline to tRNA(Pro) in a two- step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacy [...]
      
 0.887
PP_3602
2,5-dioxovalerate dehydrogenase; Function experimentally demonstrated in the studied species; enzyme; Energy metabolism.
 
 
 0.792
PP_2585
Alpha-ketoglutaric semialdehyde dehydrogenase.
 
   0.754
yveA
Aspartate-proton symporter.
  
    0.743
ocd
Ornithine cyclodeaminase 1.
 
   
 0.668
PP_3190
Ornithine cyclodeaminase/mu-crystallin family protein.
 
   
 0.666
Your Current Organism:
Pseudomonas putida KT2440
NCBI taxonomy Id: 160488
Other names: P. putida KT2440, Pseudomonas putida (strain KT2440), Pseudomonas putida str. KT2440
Server load: medium (64%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.