Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
algDGDP-mannose 6-dehydrogenase; Catalyzes the oxidation of guanosine diphospho-D-mannose (GDP-D-mannose) to GDP-D-mannuronic acid, a precursor for alginate polymerization. The alginate layer causes a mucoid phenotype and provides a protective barrier against host immune defenses and antibiotics (By similarity). (438 aa)    
Predicted Functional Partners:
alg8
Glycosyltransferase alg8; Possibly a processive enzyme that polymerizes GDP-mannuronic acid.
 
 
 0.997
algA
Mannose-6-phosphate isomerase/mannose-1-phosphate guanylyltransferase; Produces a precursor for alginate polymerization. The alginate layer provides a protective barrier against host immune defenses and antibiotics (By similarity).
 
 
 0.996
alg44
Alginate biosynthesis protein Alg44; Required for alginate biosynthesis.
  
 
 0.994
PP_1776
Mannose-6-phosphate isomerase/mannose-1-phosphate guanylyltransferase; Belongs to the mannose-6-phosphate isomerase type 2 family.
 
 
 0.967
rfbA
dTDP-glucose pyrophosphorylase; Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis. Belongs to the glucose-1-phosphate thymidylyltransferase family.
  
 
 0.963
algX
Alginate biosynthesis protein AlgX; Plays two roles in the biosynthesis of the exopolysaccharide alginate: protects alginate from degradation as the polymer traverses the periplasm, and also plays a role in its O-acetylation. Probably has acetyltransferase activity in vivo (By similarity).
 
  
 0.959
galU
UTP-glucose-1-phosphate uridylyltransferase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Energymetabolism : Sugars.
 
 0.958
algK
Alginate biosynthesis protein AlgK; May be involved in the polymerization of mannuronate to alginate.
  
  
 0.948
algE
Alginate production protein AlgE; Has non-porin-like, channel-forming properties and probably functions as an alginate permeability pore.
  
  
 0.942
gmd
GDP-mannose 4,6-dehydratase; Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6- deoxy-D-mannose.
 
 
 0.932
Your Current Organism:
Pseudomonas putida KT2440
NCBI taxonomy Id: 160488
Other names: P. putida KT2440, Pseudomonas putida (strain KT2440), Pseudomonas putida str. KT2440
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