STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
mdeAMethionine gamma-lyase; Function experimentally demonstrated in the studied strain; enzyme; Fattyacidandphospholipidmetabolism : Degradation. (398 aa)    
Predicted Functional Partners:
metH
Cobalamin-dependent methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.
  
 
 0.972
metE
5-methyltetrahydropteroyltriglutamate- homocysteine methyltransferase.
  
 
 0.957
PP_4637
5-methyltetrahydropteroyltriglutamate- homocysteine S-methyltransferase family protein; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family.
  
 
 0.939
cysK
Cysteine synthase A; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Aminoacidbiosynthesis : Serine family; Belongs to the cysteine synthase/cystathionine beta- synthase family.
 
 0.930
metG
Methionine--tRNA ligase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
   
 
 0.924
metK
Methionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
   
 0.921
msrC
Free methionine-(R)-sulfoxide reductase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Unknown function.
     
 0.916
PP_4594
Putative Cystathionine gamma-synthase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology.
  
  
 
0.910
tyrB
Aromatic-amino-acid aminotransferase; Function experimentally demonstrated in the studied strain; enzyme; Aminoacidbiosynthesis : Aspartate family.
   
 
 0.907
amaC
D-lysine aminotransferase; Function experimentally demonstrated in the studied strain; enzyme; Aminoacidbiosynthesis : Aromatic amino acid family.
   
 
 0.907
Your Current Organism:
Pseudomonas putida KT2440
NCBI taxonomy Id: 160488
Other names: P. putida KT2440, Pseudomonas putida (strain KT2440), Pseudomonas putida str. KT2440
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