Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
mdfAPutative multidrug efflux MFS transporter; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative transporter; Transport and binding proteins. (414 aa)    
Predicted Functional Partners:
emrB
Multidrug efflux transport system - permease subunit; Function of homologous gene experimentally demonstrated in an other organism; transporter; Transport and binding proteins; Belongs to the major facilitator superfamily.
  
   
 0.898
emrA
Multidrug efflux transport system - membrane fusion protein; Function of homologous gene experimentally demonstrated in an other organism; transporter; Transport and binding proteins.
   
 
 0.810
tolC
Agglutination protein.
  
 
 0.808
norM
Probable multidrug resistance protein NorM; Multidrug efflux pump; Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.
     
 0.772
pvdT
Pyoverdine efflux carrier and ATP binding protein; Part of the tripartite efflux system MacAB-TolC. MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides.
   
 
 0.624
oprN
Multidrug efflux RND outer membrane protein OprN.
   
 
 0.590
mexB
Multidrug resistance protein MexB.
      
 0.561
ttgR
Probable HTH-type transcriptional regulator TtgR; Probable regulatory protein for the ttgABC efflux pump operon. May function as a repressor (By similarity).
      
 0.549
mdeA
Methionine gamma-lyase; Function experimentally demonstrated in the studied strain; enzyme; Fattyacidandphospholipidmetabolism : Degradation.
      
 0.522
PP_1353
Homologs of previously reported genes of unknown function.
       0.496
Your Current Organism:
Pseudomonas putida KT2440
NCBI taxonomy Id: 160488
Other names: P. putida KT2440, Pseudomonas putida (strain KT2440), Pseudomonas putida str. KT2440
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