STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ttgRProbable HTH-type transcriptional regulator TtgR; Probable regulatory protein for the ttgABC efflux pump operon. May function as a repressor (By similarity). (210 aa)    
Predicted Functional Partners:
ttgA
Probable efflux pump periplasmic linker TtgA; Probable periplasmic linker protein component of the TtgABC efflux pump with unknown specificity; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.
  
  
 0.923
ttgC
Probable efflux pump outer membrane protein TtgC; Probable outer membrane component of the TtgABC efflux pump with unknown specificity; Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.
  
  
 0.839
ttgB
Probable efflux pump membrane transporter TtgB; Probable membrane transporter component of the TtgABC efflux pump with unknown specificity; Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.
     
 0.828
lexA-II
Transcriptional repressor; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.
      
 0.744
lexA-I
Transcriptional repressor; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.
   
  
 0.656
mdfA
Putative multidrug efflux MFS transporter; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative transporter; Transport and binding proteins.
      
 0.647
mexB
Multidrug resistance protein MexB.
     
 0.588
mexT
Transcriptional regulator MexT; Belongs to the LysR transcriptional regulatory family.
    
 
 0.561
PP_1517
RND efflux transporter; Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.
  
  
 0.492
oprN
Multidrug efflux RND outer membrane protein OprN.
     
 0.490
Your Current Organism:
Pseudomonas putida KT2440
NCBI taxonomy Id: 160488
Other names: P. putida KT2440, Pseudomonas putida (strain KT2440), Pseudomonas putida str. KT2440
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.