STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
sdhEConserved protein of unknown function, DUF339 family; An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH and other flavinyl [...] (84 aa)    
Predicted Functional Partners:
PP_1425
Homologs of previously reported genes of unknown function.
  
    0.811
sdhD
Succinate dehydrogenase hydrophobic membrane anchor subunit; Membrane-anchoring subunit of succinate dehydrogenase (SDH).
 
     0.779
sdhC
Succinate dehydrogenase membrane b-556 subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Energymetabolism : Aerobic.
 
   
 0.735
sdhA
Succinate dehydrogenase flavoprotein subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Energymetabolism : Aerobic; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.
 
 
 0.709
PP_0097
Homologs of previously reported genes of unknown function.
  
    0.702
PP_1423
Homologs of previously reported genes of unknown function; Belongs to the GcvT family.
 
     0.656
PP_0205
Putative Oxidoreductase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology.
  
 
 0.630
PP_4918
Homologs of previously reported genes of unknown function.
  
     0.616
PP_2600
Homologs of previously reported genes of unknown function.
  
 
 0.614
PP_2605
Homologs of previously reported genes of unknown function.
  
 
 0.614
Your Current Organism:
Pseudomonas putida KT2440
NCBI taxonomy Id: 160488
Other names: P. putida KT2440, Pseudomonas putida (strain KT2440), Pseudomonas putida str. KT2440
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.