mucB protein (Pseudomonas putida KT2440) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene Fusion

Co-occurrence

Co-expression

Experiments

Databases

Textmining

[Homology]

Score

mucB

Sigma factor AlgU regulatory protein MucB. (321 aa)

Predicted Functional Partners:

mucA

0.999

rpoE

0.968

PP_1430

0.889

algR

0.876

algC

0.778

algB

0.777

algD

0.777

recO

0.766

kinB

0.749

rseP

0.739

Your Current Organism:

Pseudomonas putida KT2440

NCBI taxonomy Id: 160488
Other names: P. putida KT2440, Pseudomonas putida (strain KT2440), Pseudomonas putida str. KT2440

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
PP_1430	algB	PP_1430	PP_0133	Putative periplasmic serine endoprotease DegP-like; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Belongs to the peptidase S1C family.	Alginate biosynthesis transcriptional regulatory protein AlgB; Positive regulator of the alginate biosynthetic gene algD.	0.609
PP_1430	algC	PP_1430	PP_5288	Putative periplasmic serine endoprotease DegP-like; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Belongs to the peptidase S1C family.	Phosphomannomutase/phosphoglucomutase; The phosphomannomutase activity produces a precursor for alginate polymerization. The alginate layer causes a mucoid phenotype and provides a protective barrier against host immune defenses and antibiotics. Also involved in core-LPS biosynthesis due to its phosphoglucomutase activity. Essential for biofilm production (By similarity).	0.444
PP_1430	mucA	PP_1430	PP_1428	Putative periplasmic serine endoprotease DegP-like; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Belongs to the peptidase S1C family.	Sigma factor AlgU negative regulatory protein.	0.973
PP_1430	mucB	PP_1430	PP_1429	Putative periplasmic serine endoprotease DegP-like; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Belongs to the peptidase S1C family.	Sigma factor AlgU regulatory protein MucB.	0.889
PP_1430	recO	PP_1430	PP_1435	Putative periplasmic serine endoprotease DegP-like; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Belongs to the peptidase S1C family.	DNA repair protein RecO; Involved in DNA repair and RecF pathway recombination.	0.649
PP_1430	rpoE	PP_1430	PP_1427	Putative periplasmic serine endoprotease DegP-like; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Belongs to the peptidase S1C family.	RNA polymerase sigma E factor; Function of homologous gene experimentally demonstrated in an other organism; factor; Transcription; Belongs to the sigma-70 factor family. ECF subfamily.	0.867
PP_1430	rseP	PP_1430	PP_1598	Putative periplasmic serine endoprotease DegP-like; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Belongs to the peptidase S1C family.	Regulatory intramembrane protein RIP zinc protease; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Regulatoryfunctions : Protein interactions.	0.511
algB	PP_1430	PP_0133	PP_1430	Alginate biosynthesis transcriptional regulatory protein AlgB; Positive regulator of the alginate biosynthetic gene algD.	Putative periplasmic serine endoprotease DegP-like; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Belongs to the peptidase S1C family.	0.609
algB	algC	PP_0133	PP_5288	Alginate biosynthesis transcriptional regulatory protein AlgB; Positive regulator of the alginate biosynthetic gene algD.	Phosphomannomutase/phosphoglucomutase; The phosphomannomutase activity produces a precursor for alginate polymerization. The alginate layer causes a mucoid phenotype and provides a protective barrier against host immune defenses and antibiotics. Also involved in core-LPS biosynthesis due to its phosphoglucomutase activity. Essential for biofilm production (By similarity).	0.710
algB	algD	PP_0133	PP_1288	Alginate biosynthesis transcriptional regulatory protein AlgB; Positive regulator of the alginate biosynthetic gene algD.	GDP-mannose 6-dehydrogenase; Catalyzes the oxidation of guanosine diphospho-D-mannose (GDP-D-mannose) to GDP-D-mannuronic acid, a precursor for alginate polymerization. The alginate layer causes a mucoid phenotype and provides a protective barrier against host immune defenses and antibiotics (By similarity).	0.760
algB	algR	PP_0133	PP_0185	Alginate biosynthesis transcriptional regulatory protein AlgB; Positive regulator of the alginate biosynthetic gene algD.	Positive alginate biosynthesis regulatory protein.	0.816
algB	kinB	PP_0133	PP_0132	Alginate biosynthesis transcriptional regulatory protein AlgB; Positive regulator of the alginate biosynthetic gene algD.	Alginate biosynthesis sensor protein KinB.	0.999
algB	mucA	PP_0133	PP_1428	Alginate biosynthesis transcriptional regulatory protein AlgB; Positive regulator of the alginate biosynthetic gene algD.	Sigma factor AlgU negative regulatory protein.	0.774
algB	mucB	PP_0133	PP_1429	Alginate biosynthesis transcriptional regulatory protein AlgB; Positive regulator of the alginate biosynthetic gene algD.	Sigma factor AlgU regulatory protein MucB.	0.777
algB	rpoE	PP_0133	PP_1427	Alginate biosynthesis transcriptional regulatory protein AlgB; Positive regulator of the alginate biosynthetic gene algD.	RNA polymerase sigma E factor; Function of homologous gene experimentally demonstrated in an other organism; factor; Transcription; Belongs to the sigma-70 factor family. ECF subfamily.	0.651
algC	PP_1430	PP_5288	PP_1430	Phosphomannomutase/phosphoglucomutase; The phosphomannomutase activity produces a precursor for alginate polymerization. The alginate layer causes a mucoid phenotype and provides a protective barrier against host immune defenses and antibiotics. Also involved in core-LPS biosynthesis due to its phosphoglucomutase activity. Essential for biofilm production (By similarity).	Putative periplasmic serine endoprotease DegP-like; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Belongs to the peptidase S1C family.	0.444
algC	algB	PP_5288	PP_0133	Phosphomannomutase/phosphoglucomutase; The phosphomannomutase activity produces a precursor for alginate polymerization. The alginate layer causes a mucoid phenotype and provides a protective barrier against host immune defenses and antibiotics. Also involved in core-LPS biosynthesis due to its phosphoglucomutase activity. Essential for biofilm production (By similarity).	Alginate biosynthesis transcriptional regulatory protein AlgB; Positive regulator of the alginate biosynthetic gene algD.	0.710
algC	algD	PP_5288	PP_1288	Phosphomannomutase/phosphoglucomutase; The phosphomannomutase activity produces a precursor for alginate polymerization. The alginate layer causes a mucoid phenotype and provides a protective barrier against host immune defenses and antibiotics. Also involved in core-LPS biosynthesis due to its phosphoglucomutase activity. Essential for biofilm production (By similarity).	GDP-mannose 6-dehydrogenase; Catalyzes the oxidation of guanosine diphospho-D-mannose (GDP-D-mannose) to GDP-D-mannuronic acid, a precursor for alginate polymerization. The alginate layer causes a mucoid phenotype and provides a protective barrier against host immune defenses and antibiotics (By similarity).	0.914
algC	algR	PP_5288	PP_0185	Phosphomannomutase/phosphoglucomutase; The phosphomannomutase activity produces a precursor for alginate polymerization. The alginate layer causes a mucoid phenotype and provides a protective barrier against host immune defenses and antibiotics. Also involved in core-LPS biosynthesis due to its phosphoglucomutase activity. Essential for biofilm production (By similarity).	Positive alginate biosynthesis regulatory protein.	0.834
algC	kinB	PP_5288	PP_0132	Phosphomannomutase/phosphoglucomutase; The phosphomannomutase activity produces a precursor for alginate polymerization. The alginate layer causes a mucoid phenotype and provides a protective barrier against host immune defenses and antibiotics. Also involved in core-LPS biosynthesis due to its phosphoglucomutase activity. Essential for biofilm production (By similarity).	Alginate biosynthesis sensor protein KinB.	0.564