node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
PP_2276 | PP_3988 | PP_2276 | PP_3988 | Putative phage exonuclease; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Mobileandextrachromosomalelementfunctions : Prophage functions. | Homologs of previously reported genes of unknown function. | 0.734 |
PP_2276 | dnaN | PP_2276 | PP_0011 | Putative phage exonuclease; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Mobileandextrachromosomalelementfunctions : Prophage functions. | DNA polymerase III subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | 0.924 |
PP_2276 | mutL | PP_2276 | PP_4896 | Putative phage exonuclease; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Mobileandextrachromosomalelementfunctions : Prophage functions. | DNA mismatch repair protein MutL; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. | 0.734 |
PP_2276 | mutS | PP_2276 | PP_1626 | Putative phage exonuclease; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Mobileandextrachromosomalelementfunctions : Prophage functions. | DNA mismatch repair protein MutS; This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity. | 0.840 |
PP_2276 | polA | PP_2276 | PP_0123 | Putative phage exonuclease; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Mobileandextrachromosomalelementfunctions : Prophage functions. | DNA polymerase I, 5' -> 3' polymerase with 5' --> 3' and 3' --> 5' exonuclease activity; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.948 |
PP_2276 | recA | PP_2276 | PP_1629 | Putative phage exonuclease; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Mobileandextrachromosomalelementfunctions : Prophage functions. | Protein RecA; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. | 0.778 |
PP_2276 | recQ | PP_2276 | PP_4516 | Putative phage exonuclease; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Mobileandextrachromosomalelementfunctions : Prophage functions. | ATP-dependent DNA 3' to 5' helicase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; DNA metabolism. | 0.850 |
PP_3988 | PP_2276 | PP_3988 | PP_2276 | Homologs of previously reported genes of unknown function. | Putative phage exonuclease; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Mobileandextrachromosomalelementfunctions : Prophage functions. | 0.734 |
PP_3988 | dnaN | PP_3988 | PP_0011 | Homologs of previously reported genes of unknown function. | DNA polymerase III subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | 0.787 |
PP_3988 | mutS | PP_3988 | PP_1626 | Homologs of previously reported genes of unknown function. | DNA mismatch repair protein MutS; This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity. | 0.950 |
PP_3988 | polA | PP_3988 | PP_0123 | Homologs of previously reported genes of unknown function. | DNA polymerase I, 5' -> 3' polymerase with 5' --> 3' and 3' --> 5' exonuclease activity; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.825 |
PP_3988 | recA | PP_3988 | PP_1629 | Homologs of previously reported genes of unknown function. | Protein RecA; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. | 0.513 |
PP_3988 | recQ | PP_3988 | PP_4516 | Homologs of previously reported genes of unknown function. | ATP-dependent DNA 3' to 5' helicase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; DNA metabolism. | 0.708 |
cycA | mutS | PP_4840 | PP_1626 | D-alanine, beta-alanine, D-serine, glycine permease; Function of homologous gene experimentally demonstrated in an other organism; transporter; Biologicalprocesses : Circulate. | DNA mismatch repair protein MutS; This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity. | 0.649 |
cycA | sdaC | PP_4840 | PP_3589 | D-alanine, beta-alanine, D-serine, glycine permease; Function of homologous gene experimentally demonstrated in an other organism; transporter; Biologicalprocesses : Circulate. | serine:H+ symport permease, threonine-insensitive; Function of strongly homologous gene; transporter; Aminoacidbiosynthesis : Serine family. | 0.835 |
dinB | dnaN | PP_1203 | PP_0011 | DNA polymerase IV; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. | DNA polymerase III subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | 0.926 |
dinB | mutL | PP_1203 | PP_4896 | DNA polymerase IV; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. | DNA mismatch repair protein MutL; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. | 0.510 |
dinB | mutS | PP_1203 | PP_1626 | DNA polymerase IV; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. | DNA mismatch repair protein MutS; This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity. | 0.755 |
dinB | polA | PP_1203 | PP_0123 | DNA polymerase IV; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. | DNA polymerase I, 5' -> 3' polymerase with 5' --> 3' and 3' --> 5' exonuclease activity; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.698 |
dinB | recA | PP_1203 | PP_1629 | DNA polymerase IV; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. | Protein RecA; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. | 0.934 |