| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| PP_2013 | tpm | PP_2013 | PP_1870 | Homologs of previously reported genes of unknown function. | Putative thiopurine S-methyltransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Belongs to the class I-like SAM-binding methyltransferase superfamily. TPMT family. | 0.443 |
| PP_2029 | tpm | PP_2029 | PP_1870 | Von Willebrand factor type A domain protein. | Putative thiopurine S-methyltransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Belongs to the class I-like SAM-binding methyltransferase superfamily. TPMT family. | 0.426 |
| PP_2343 | tpm | PP_2343 | PP_1870 | Homologs of previously reported genes of unknown function. | Putative thiopurine S-methyltransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Belongs to the class I-like SAM-binding methyltransferase superfamily. TPMT family. | 0.443 |
| dadA-II | tpm | PP_5270 | PP_1870 | D-amino-acid:quinone oxidoreductase (deaminating); Oxidative deamination of D-amino acids; Belongs to the DadA oxidoreductase family. | Putative thiopurine S-methyltransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Belongs to the class I-like SAM-binding methyltransferase superfamily. TPMT family. | 0.934 |
| metH | queF | PP_2375 | PP_2160 | Cobalamin-dependent methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | NADPH-dependent 7-cyano-7-deazaguanine reductase; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). | 0.415 |
| metH | tpm | PP_2375 | PP_1870 | Cobalamin-dependent methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Putative thiopurine S-methyltransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Belongs to the class I-like SAM-binding methyltransferase superfamily. TPMT family. | 0.407 |
| queF | metH | PP_2160 | PP_2375 | NADPH-dependent 7-cyano-7-deazaguanine reductase; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). | Cobalamin-dependent methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.415 |
| queF | tpm | PP_2160 | PP_1870 | NADPH-dependent 7-cyano-7-deazaguanine reductase; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). | Putative thiopurine S-methyltransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Belongs to the class I-like SAM-binding methyltransferase superfamily. TPMT family. | 0.407 |
| tpm | PP_2013 | PP_1870 | PP_2013 | Putative thiopurine S-methyltransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Belongs to the class I-like SAM-binding methyltransferase superfamily. TPMT family. | Homologs of previously reported genes of unknown function. | 0.443 |
| tpm | PP_2029 | PP_1870 | PP_2029 | Putative thiopurine S-methyltransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Belongs to the class I-like SAM-binding methyltransferase superfamily. TPMT family. | Von Willebrand factor type A domain protein. | 0.426 |
| tpm | PP_2343 | PP_1870 | PP_2343 | Putative thiopurine S-methyltransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Belongs to the class I-like SAM-binding methyltransferase superfamily. TPMT family. | Homologs of previously reported genes of unknown function. | 0.443 |
| tpm | dadA-II | PP_1870 | PP_5270 | Putative thiopurine S-methyltransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Belongs to the class I-like SAM-binding methyltransferase superfamily. TPMT family. | D-amino-acid:quinone oxidoreductase (deaminating); Oxidative deamination of D-amino acids; Belongs to the DadA oxidoreductase family. | 0.934 |
| tpm | metH | PP_1870 | PP_2375 | Putative thiopurine S-methyltransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Belongs to the class I-like SAM-binding methyltransferase superfamily. TPMT family. | Cobalamin-dependent methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.407 |
| tpm | queF | PP_1870 | PP_2160 | Putative thiopurine S-methyltransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Belongs to the class I-like SAM-binding methyltransferase superfamily. TPMT family. | NADPH-dependent 7-cyano-7-deazaguanine reductase; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). | 0.407 |
| tpm | ygiD | PP_1870 | PP_1869 | Putative thiopurine S-methyltransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Belongs to the class I-like SAM-binding methyltransferase superfamily. TPMT family. | 4,5-DOPA-dioxygenase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Fattyacidandphospholipidmetabolism : Biosynthesis. | 0.579 |
| ygiD | tpm | PP_1869 | PP_1870 | 4,5-DOPA-dioxygenase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Fattyacidandphospholipidmetabolism : Biosynthesis. | Putative thiopurine S-methyltransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Belongs to the class I-like SAM-binding methyltransferase superfamily. TPMT family. | 0.579 |