Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
tyrBAromatic-amino-acid aminotransferase; Function experimentally demonstrated in the studied strain; enzyme; Aminoacidbiosynthesis : Aspartate family. (398 aa)    
Predicted Functional Partners:
pheA
Chorismate mutase/Prephenate dehydratase; Function of strongly homologous gene; enzyme.
    
 0.992
hpd
4-hydroxyphenylpyruvate dioxygenase; Function experimentally demonstrated in the studied strain; enzyme; Energymetabolism : Amino acids and amines.
  
 
 0.986
phhA
Phenylalanine-4-hydroxylase; Function experimentally demonstrated in the studied strain; enzyme; Fattyacidandphospholipidmetabolism : Degradation.
  
 
 0.980
aroA
3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
    
 0.978
hisC
Histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
   
 
 0.935
mdeA
Methionine gamma-lyase; Function experimentally demonstrated in the studied strain; enzyme; Fattyacidandphospholipidmetabolism : Degradation.
   
 0.918
metH
Cobalamin-dependent methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.
     
 0.918
PP_1832
Putative Oxidase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology.
     
 0.917
metK
Methionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
   
 
 0.913
PP_2552
DOPA decarboxylase.
   
 
 0.908
Your Current Organism:
Pseudomonas putida KT2440
NCBI taxonomy Id: 160488
Other names: P. putida KT2440, Pseudomonas putida (strain KT2440), Pseudomonas putida str. KT2440
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