node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
PP_1832 | metH | PP_1832 | PP_2375 | Putative Oxidase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. | Cobalamin-dependent methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.730 |
PP_1832 | tyrB | PP_1832 | PP_1972 | Putative Oxidase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. | Aromatic-amino-acid aminotransferase; Function experimentally demonstrated in the studied strain; enzyme; Aminoacidbiosynthesis : Aspartate family. | 0.912 |
PP_2552 | aroA | PP_2552 | PP_1770 | DOPA decarboxylase. | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. | 0.808 |
PP_2552 | hisC | PP_2552 | PP_0967 | DOPA decarboxylase. | Histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.905 |
PP_2552 | hpd | PP_2552 | PP_3433 | DOPA decarboxylase. | 4-hydroxyphenylpyruvate dioxygenase; Function experimentally demonstrated in the studied strain; enzyme; Energymetabolism : Amino acids and amines. | 0.491 |
PP_2552 | pheA | PP_2552 | PP_1769 | DOPA decarboxylase. | Chorismate mutase/Prephenate dehydratase; Function of strongly homologous gene; enzyme. | 0.877 |
PP_2552 | phhA | PP_2552 | PP_4490 | DOPA decarboxylase. | Phenylalanine-4-hydroxylase; Function experimentally demonstrated in the studied strain; enzyme; Fattyacidandphospholipidmetabolism : Degradation. | 0.928 |
PP_2552 | quiC | PP_2552 | PP_2554 | DOPA decarboxylase. | Putative 3-dehydroshikimate dehydratase; Catalyzes the conversion of 3-dehydroshikimate to protocatechuate (3,4-dihydroxybenzoate), a common intermediate of quinate and shikimate degradation pathways. | 0.480 |
PP_2552 | tyrB | PP_2552 | PP_1972 | DOPA decarboxylase. | Aromatic-amino-acid aminotransferase; Function experimentally demonstrated in the studied strain; enzyme; Aminoacidbiosynthesis : Aspartate family. | 0.911 |
aroA | PP_2552 | PP_1770 | PP_2552 | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. | DOPA decarboxylase. | 0.808 |
aroA | hisC | PP_1770 | PP_0967 | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. | Histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.995 |
aroA | hpd | PP_1770 | PP_3433 | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. | 4-hydroxyphenylpyruvate dioxygenase; Function experimentally demonstrated in the studied strain; enzyme; Energymetabolism : Amino acids and amines. | 0.444 |
aroA | metH | PP_1770 | PP_2375 | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. | Cobalamin-dependent methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.583 |
aroA | pheA | PP_1770 | PP_1769 | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. | Chorismate mutase/Prephenate dehydratase; Function of strongly homologous gene; enzyme. | 0.999 |
aroA | phhA | PP_1770 | PP_4490 | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. | Phenylalanine-4-hydroxylase; Function experimentally demonstrated in the studied strain; enzyme; Fattyacidandphospholipidmetabolism : Degradation. | 0.929 |
aroA | quiC | PP_1770 | PP_2554 | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. | Putative 3-dehydroshikimate dehydratase; Catalyzes the conversion of 3-dehydroshikimate to protocatechuate (3,4-dihydroxybenzoate), a common intermediate of quinate and shikimate degradation pathways. | 0.509 |
aroA | tyrB | PP_1770 | PP_1972 | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. | Aromatic-amino-acid aminotransferase; Function experimentally demonstrated in the studied strain; enzyme; Aminoacidbiosynthesis : Aspartate family. | 0.978 |
hisC | PP_2552 | PP_0967 | PP_2552 | Histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | DOPA decarboxylase. | 0.905 |
hisC | aroA | PP_0967 | PP_1770 | Histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. | 0.995 |
hisC | hpd | PP_0967 | PP_3433 | Histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 4-hydroxyphenylpyruvate dioxygenase; Function experimentally demonstrated in the studied strain; enzyme; Energymetabolism : Amino acids and amines. | 0.914 |