Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
sbcDExonuclease SbcD; SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity; Belongs to the SbcD family. (412 aa)    
Predicted Functional Partners:
sbcC
Exonuclease SbcC.
 0.999
polA
DNA polymerase I, 5' -> 3' polymerase with 5' --> 3' and 3' --> 5' exonuclease activity; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
  
 0.949
PP_0693
Homologs of previously reported genes of unknown function.
  
 0.945
PP_1105
Putative DNA ligase, ATP-dependent; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology.
  
 0.880
rapA
RNA polymerase-associated protein RapA; Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair; Belongs to the SNF2/RAD54 helicase family. RapA subfamily.
 
 
 0.872
PP_2023
Glutathione S-transferase family protein.
       0.869
recQ
ATP-dependent DNA 3' to 5' helicase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; DNA metabolism.
  
 0.863
PP_1102
Homologs of previously reported genes of unknown function.
      
 0.816
recA
Protein RecA; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family.
  
 0.808
PP_2276
Putative phage exonuclease; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Mobileandextrachromosomalelementfunctions : Prophage functions.
   
 0.744
Your Current Organism:
Pseudomonas putida KT2440
NCBI taxonomy Id: 160488
Other names: P. putida KT2440, Pseudomonas putida (strain KT2440), Pseudomonas putida str. KT2440
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