Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
acnA-IIAconitate hydratase 1; Function of strongly homologous gene; enzyme; Energymetabolism : Anaerobic. (862 aa)    
Predicted Functional Partners:
prpC
Methylcitrate synthase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Energy metabolism; Belongs to the citrate synthase family.
 
 0.999
prpF
Aconitate isomerase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Energy metabolism.
 
 
 0.999
prpD
2-methylcitrate dehydratase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Energy metabolism.
  
 
 0.965
icd
Isocitrate dehydrogenase, NADP(+)-specific; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Energymetabolism : Anaerobic.
 
 0.926
gltA
Citrate synthase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Energymetabolism : Anaerobic; Belongs to the citrate synthase family.
 
 0.925
fumC-II
Fumarate hydratase (class 2); Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.
  
 0.834
fumC-I
Fumarate hydratase (class 2); Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.
  
 0.830
PP_2330
Homologs of previously reported genes of unknown function.
     
 0.808
mdh
Putative malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily.
  
 0.800
mmgF
2-methylisocitrate lyase; Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate. Belongs to the isocitrate lyase/PEP mutase superfamily. Methylisocitrate lyase family.
 
 
 0.800
Your Current Organism:
Pseudomonas putida KT2440
NCBI taxonomy Id: 160488
Other names: P. putida KT2440, Pseudomonas putida (strain KT2440), Pseudomonas putida str. KT2440
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