Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
prpEpropionyl-CoA synthetase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Energy metabolism. (629 aa)    
Predicted Functional Partners:
prpC
Methylcitrate synthase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Energy metabolism; Belongs to the citrate synthase family.
  
 0.982
PP_0596
Omega-amino acid--pyruvate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
     
 0.970
PP_2213
Putative acyl-CoA synthetase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme.
  
 
0.944
pta
Phosphate acetyltransferase; Involved in acetate metabolism; In the N-terminal section; belongs to the CobB/CobQ family.
    
 0.929
mmsA-II
Methylmalonate-semialdehyde dehydrogenase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Biologicalprocesses : Scavenge (Catabolism).
   
 0.926
mmsA-I
Methylmalonate-semialdehyde dehydrogenase; Function of strongly homologous gene; enzyme.
   
 0.925
acsA-I
acetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family.
  
 
0.920
acd
Short-chain acyl-CoA dehydrogenase; Function experimentally demonstrated in the studied strain; enzyme; Biologicalprocesses : Scavenge (Catabolism).
   
 
 0.917
mmsB
3-hydroxyisobutyrate dehydrogenase; Belongs to the HIBADH-related family.
  
 
 0.915
acsA-II
acetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family.
  
 
0.914
Your Current Organism:
Pseudomonas putida KT2440
NCBI taxonomy Id: 160488
Other names: P. putida KT2440, Pseudomonas putida (strain KT2440), Pseudomonas putida str. KT2440
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