STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
nfuAFe/S biogenesis protein NfuA; Involved in iron-sulfur cluster biogenesis. Binds a 4Fe-4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe/S proteins. Could also act as a scaffold/chaperone for damaged Fe/S proteins. (194 aa)    
Predicted Functional Partners:
iscU
Scaffold protein involved in iron-sulfur cluster assembly; A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters.
  
 
 0.980
grxD
Monothiol glutaredoxin 4; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Energymetabolism : Electron transport; Belongs to the glutaredoxin family. Monothiol subfamily.
  
 0.899
iscS-I
Cysteine desulfurase; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.
  
 
 0.885
iscS-II
Cysteine desulfurase; Function of strongly homologous gene; enzyme.
  
 
 0.885
PP_4350
Aminotransferase, class V, NifS/IscS family.
  
 
 0.885
sdhB
Succinate dehydrogenase iron-sulfur subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Energymetabolism : Aerobic.
  
 
 0.861
djlA
DnaJ-like protein DjlA.
  
 
 0.860
hscB
DnaJ-like molecular chaperone specific for IscU; Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA; Belongs to the HscB family.
  
 
 0.860
iscR
DNA-binding transcriptional dual regulator 2Fe-2S cluster IscR; Regulates the transcription of several operons and genes involved in the biogenesis of Fe-S clusters and Fe-S-containing proteins.
 
  
 0.849
yfhL
Putative 4Fe-4S cluster-containing protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; carrier; Energymetabolism : Electron transport.
  
  
 0.811
Your Current Organism:
Pseudomonas putida KT2440
NCBI taxonomy Id: 160488
Other names: P. putida KT2440, Pseudomonas putida (strain KT2440), Pseudomonas putida str. KT2440
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