STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PP_2585Alpha-ketoglutaric semialdehyde dehydrogenase. (526 aa)    
Predicted Functional Partners:
PP_1257
Putative 1-pyrroline-4-hydroxy-2-carboxylate deaminase; No homology to any previously reported sequences; putative enzyme; Energymetabolism : Amino acids and amines; Belongs to the DapA family.
 
 
 0.962
kdgD
5-dehydro-4-deoxyglucarate dehydratase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Fattyacidandphospholipidmetabolism : Degradation; Belongs to the DapA family.
 
 
 0.958
PP_1256
Putative alpha-ketoglutarate semialdehyde dehydrogenase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Energymetabolism : Amino acids and amines.
  
  
 
0.904
PP_3602
2,5-dioxovalerate dehydrogenase; Function experimentally demonstrated in the studied species; enzyme; Energy metabolism.
  
  
 
0.901
sucA
2-oxoglutarate decarboxylase, thiamine-requiring E1 subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Energymetabolism : TCA cycle.
   
 
 0.824
icd
Isocitrate dehydrogenase, NADP(+)-specific; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Energymetabolism : Anaerobic.
   
 0.813
idh
Isocitrate dehydrogenase; Function of strongly homologous gene; enzyme; Belongs to the monomeric-type IDH family.
   
 
  0.805
prpA
4-hydroxyproline epimerase; Catalyzes the reversible epimerization of cis-4-hydroxy-D- proline (c4DHyp) to trans-4-hydroxy-L-proline (t4LHyp). May be involved in a degradation pathway that allows P.putida strain KT2440 to grow on either epimer of 4-hydroxyproline, c4DHyp and t4LHyp, as the sole carbon and nitrogen source. Does not exhibit measureable racemase activity in vitro with any of the 19 natural chiral amino acid enantiomers.
 
   0.754
PP_2836
Putative 2-keto-3-deoxyxylonate dehydratase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Energymetabolism : Sugars.
    0.646
dhaT
1,3-propanediol dehydrogenase.
  
 
 0.602
Your Current Organism:
Pseudomonas putida KT2440
NCBI taxonomy Id: 160488
Other names: P. putida KT2440, Pseudomonas putida (strain KT2440), Pseudomonas putida str. KT2440
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