STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PP_2673Pentapeptide repeat family protein. (219 aa)    
Predicted Functional Partners:
qedH-I
Quinoprotein ethanol dehydrogenase; Function experimentally demonstrated in the studied species; enzyme; Energy metabolism.
 
  
 0.949
qedH-II
Quinoprotein ethanol dehydrogenase; Function experimentally demonstrated in the studied species; enzyme; Energy metabolism.
 
  
 0.880
PP_2675
Cytochrome c-type protein.
 
    0.841
PP_2663
Homologs of previously reported genes of unknown function.
  
  
 0.794
PP_2662
Homologs of previously reported genes of unknown function.
  
  
 0.668
PP_2677
Homologs of previously reported genes of unknown function.
 
    0.540
gyrB
DNA gyrase subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
   
 
 0.535
parE
DNA topoisomerase IV subunit B; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule; Belongs to the type II topoisomerase family. ParE type 1 subfamily.
   
 
 0.535
PP_2678
Putative Hydrolase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology.
 
 
 0.530
iorA-II
Isoquinoline 1-oxidoreductase subunit alpha; Function of homologous gene experimentally demonstrated in an other organism; enzyme.
   
  
 0.518
Your Current Organism:
Pseudomonas putida KT2440
NCBI taxonomy Id: 160488
Other names: P. putida KT2440, Pseudomonas putida (strain KT2440), Pseudomonas putida str. KT2440
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.