Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
arsHArsH protein. (233 aa)    
Predicted Functional Partners:
arsR-II
Arsenic resistance transcriptional regulator; Binds arsenite and regulates the expression of arsenic efflux pumps. In vitro, also binds antimony and bismuth, but not arsenate.
  
  
 0.923
PP_2716
Arsenate reductase; Function of strongly homologous gene; enzyme; Belongs to the low molecular weight phosphotyrosine protein phosphatase family.
  
  
 0.865
arsB-II
Arsenite/antimonite transporter; Involved in arsenical resistance. Thought to form the channel of an arsenite pump; Belongs to the ArsB family.
  
  
 0.848
chrR
Chromate reductase; Catalyzes the reduction of quinones. Acts by simultaneous two-electron transfer, avoiding formation of highly reactive semiquinone intermediates and producing quinols that promote tolerance of H(2)O(2). Quinone reduction is probably the primary biological role of ChrR. Can also reduce toxic chromate to insoluble and less toxic Cr(3+). Catalyzes the transfer of three electrons to Cr(6+) producing Cr(3+) and one electron to molecular oxygen. This reaction produces transiently a minimal amount of the toxic Cr(5+) species and reactive oxygen species (ROS). Chromate redu [...]
      
 0.812
arsR-I
Arsenic resistance transcriptional regulator; Binds arsenite and regulates the expression of arsenic efflux pumps. In vitro, also binds antimony and bismuth, but not arsenate.
     
 0.805
yfgD
Putative enzyme; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Cellularprocesses : Detoxification.
  
  
 0.803
czcC
Metal RND efflux outer membrane protein, CzcC family; Function experimentally demonstrated in the studied genus; factor; Biologicalprocesses : Excrete.
      
 0.771
PP_0670
Transporter, bile acid/Na+ symporter family.
     
 0.745
cusB
Probable copper RND efflux membrane fusion protein, CzcB family; Function of homologous gene experimentally demonstrated in an other organism; transporter; Biologicalprocesses : Excrete; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.
      
 0.741
PP_0820
GCN5-related N-acetyltransferase.
      
 0.714
Your Current Organism:
Pseudomonas putida KT2440
NCBI taxonomy Id: 160488
Other names: P. putida KT2440, Pseudomonas putida (strain KT2440), Pseudomonas putida str. KT2440
Server load: low (16%) [HD]