STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ampCBeta-lactamase. (380 aa)    
Predicted Functional Partners:
ampD
N-acetyl-anhydromuramyl-L-alanine-amidase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Regulatory functions.
      
 0.849
gyrA
DNA gyrase, subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
   
  
 0.774
dacB
D-alanyl-D-alanine carboxypeptidase.
     
 0.767
parC
DNA topoisomerase IV subunit A; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule; Belongs to the type II topoisomerase GyrA/ParC subunit family. ParC type 1 subfamily.
   
  
 0.759
parE
DNA topoisomerase IV subunit B; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule; Belongs to the type II topoisomerase family. ParE type 1 subfamily.
      
 0.755
oprD
Basic-amino-acid specific porin OprD; Function experimentally demonstrated in the studied genus; transporter; Transportandbindingproteins : Porins.
      
 0.751
nfxB
HTH-type transcriptional regulator nfxB.
   
  
 0.737
rpsL
30S ribosomal protein S12; With S4 and S5 plays an important role in translational accuracy.
      
 0.730
oprJ
Outer membrane protein OprJ.
   
  
 0.652
oprN
Multidrug efflux RND outer membrane protein OprN.
   
  
 0.592
Your Current Organism:
Pseudomonas putida KT2440
NCBI taxonomy Id: 160488
Other names: P. putida KT2440, Pseudomonas putida (strain KT2440), Pseudomonas putida str. KT2440
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