STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PP_3841Transcriptional regulator, MerR family. (123 aa)    
Predicted Functional Partners:
czcR-I
Two component heavy metal response regulator; Function of strongly homologous gene; regulator; Biologicalprocesses : Control.
    
 
 0.845
czcR-II
Response regulator; Function experimentally demonstrated in the studied genus; regulator; Biologicalprocesses : Control.
    
 
 0.845
czcR-III
Response regulator; Function of strongly homologous gene; regulator; Biologicalprocesses : Control.
    
 
 0.845
PP_3262
Putative Metallothionein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology.
      
 0.753
czcC
Metal RND efflux outer membrane protein, CzcC family; Function experimentally demonstrated in the studied genus; factor; Biologicalprocesses : Excrete.
  
  
 0.663
PP_3842
Homologs of previously reported genes of unknown function.
  
    0.557
rpoD
RNA polymerase, sigma 70 (sigma D) factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth.
  
 
 0.506
cbpA
Curved DNA-binding protein; DNA-binding protein that preferentially recognizes a curved DNA sequence. It is probably a functional analog of DnaJ; displays overlapping activities with DnaJ, but functions under different conditions, probably acting as a molecular chaperone in an adaptive response to environmental stresses other than heat shock. Lacks autonomous chaperone activity; binds native substrates and targets them for recognition by DnaK. Its activity is inhibited by the binding of CbpM.
  
 
 0.496
dnaJ
Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...]
  
 
 0.494
PP_3539
Putative Transcriptional regulator; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology.
  
  
 0.408
Your Current Organism:
Pseudomonas putida KT2440
NCBI taxonomy Id: 160488
Other names: P. putida KT2440, Pseudomonas putida (strain KT2440), Pseudomonas putida str. KT2440
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