STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
nicEMaleate isomerase; Catalyzes cis-trans isomerization of the C2-C3 double bond in maleate to yield fumarate in the aerobic nicotinate degradation pathway. (250 aa)    
Predicted Functional Partners:
nicF
Maleamate amidohydrolase; Maleamate amidase that transforms maleamate into maleate and ammonia in the aerobic nicotinate degradation pathway.
 
 
 0.999
nicD
N-formylmaleamate deformylase; Deformylase that catalyzes the conversion of N-formylmaleamic acid to maleamate in the aerobic nicotinate degradation pathway.
 
  
 0.995
nicX
2,5-dihydroxypyridine 5,6-dioxygenase; Catalyzes the dioxygenolytic ring cleavage of 2,5- dihydroxypyridine between carbons 5 and 6 generating N-formylmaleamate in the aerobic nicotinate degradation pathway.
 
  
 0.991
nicC
6-hydroxynicotinate 3-monooxygenase; Flavin-dependent monooxygenase (FMO) that catalyzes the decarboxylative hydroxylation of 6-hydroxynicotinic acid (6-HNA) to 2,5-dihydroxypyridine (2,5-DHP) with concomitant oxidation of NADH, a step in the aerobic nicotinate degradation pathway. Belongs to the 6-hydroxynicotinate 3-monooxygenase family.
 
  
 0.988
sdhA
Succinate dehydrogenase flavoprotein subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Energymetabolism : Aerobic; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.
   
 
  0.903
sdhB
Succinate dehydrogenase iron-sulfur subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Energymetabolism : Aerobic.
     
  0.900
sdhD
Succinate dehydrogenase hydrophobic membrane anchor subunit; Membrane-anchoring subunit of succinate dehydrogenase (SDH).
     
  0.900
sdhC
Succinate dehydrogenase membrane b-556 subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Energymetabolism : Aerobic.
     
  0.900
nicR
HTH-type transcriptional repressor NicR; Transcriptional repressor for the nicCDEFTP and nicXR operons, encoding the lower aerobic nicotinate degradation pathway. Acts under non-induced conditions: repression of the nicCDEFTP and nicXR operons becomes alleviated in presence of 6-hydroxynicotinate (6HNA).
 
  
 0.830
aspA
Aspartate ammonia-lyase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Energymetabolism : Amino acids and amines.
     
 0.826
Your Current Organism:
Pseudomonas putida KT2440
NCBI taxonomy Id: 160488
Other names: P. putida KT2440, Pseudomonas putida (strain KT2440), Pseudomonas putida str. KT2440
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