STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
nicX2,5-dihydroxypyridine 5,6-dioxygenase; Catalyzes the dioxygenolytic ring cleavage of 2,5- dihydroxypyridine between carbons 5 and 6 generating N-formylmaleamate in the aerobic nicotinate degradation pathway. (350 aa)    
Predicted Functional Partners:
nicD
N-formylmaleamate deformylase; Deformylase that catalyzes the conversion of N-formylmaleamic acid to maleamate in the aerobic nicotinate degradation pathway.
 
 
 0.999
nicC
6-hydroxynicotinate 3-monooxygenase; Flavin-dependent monooxygenase (FMO) that catalyzes the decarboxylative hydroxylation of 6-hydroxynicotinic acid (6-HNA) to 2,5-dihydroxypyridine (2,5-DHP) with concomitant oxidation of NADH, a step in the aerobic nicotinate degradation pathway. Belongs to the 6-hydroxynicotinate 3-monooxygenase family.
 
 
 0.998
nicE
Maleate isomerase; Catalyzes cis-trans isomerization of the C2-C3 double bond in maleate to yield fumarate in the aerobic nicotinate degradation pathway.
 
  
 0.991
nicR
HTH-type transcriptional repressor NicR; Transcriptional repressor for the nicCDEFTP and nicXR operons, encoding the lower aerobic nicotinate degradation pathway. Acts under non-induced conditions: repression of the nicCDEFTP and nicXR operons becomes alleviated in presence of 6-hydroxynicotinate (6HNA).
 
  
 0.980
nicF
Maleamate amidohydrolase; Maleamate amidase that transforms maleamate into maleate and ammonia in the aerobic nicotinate degradation pathway.
 
  
 0.975
pepA
Probable cytosol aminopeptidase; Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N- terminal amino acids from various peptides.
      
 0.860
nicB
Nicotinate dehydrogenase subunit B; Subunit of the two-component enzyme NicAB that mediates nicotinate hydroxylation, the first step in the aerobic nicotinate degradation pathway. Mediates conversion of nicotinate into 6- hydroxynicotinate (6HNA).
 
  
 0.851
PP_4164
Alpha/beta hydrolase.
  
  
 0.837
nicT
Putative metabolite transport protein NicT; Probable transporter, possibly involved in the aerobic nicotinate degradation pathway.
  
  
 0.792
nicA
Nicotinate dehydrogenase subunit A; Subunit of the two-component enzyme NicAB that mediates nicotinate hydroxylation, the first step in the aerobic nicotinate degradation pathway. Mediates conversion of nicotinate into 6- hydroxynicotinate (6HNA).
  
  
 0.761
Your Current Organism:
Pseudomonas putida KT2440
NCBI taxonomy Id: 160488
Other names: P. putida KT2440, Pseudomonas putida (strain KT2440), Pseudomonas putida str. KT2440
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