| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| PP_2478 | nicA | PP_2478 | PP_3947 | Putative Isoquinoline 1-oxidoreductase, beta subunit; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. | Nicotinate dehydrogenase subunit A; Subunit of the two-component enzyme NicAB that mediates nicotinate hydroxylation, the first step in the aerobic nicotinate degradation pathway. Mediates conversion of nicotinate into 6- hydroxynicotinate (6HNA). | 0.960 |
| PP_3361 | nicA | PP_3361 | PP_3947 | Putative aminotransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Unknownfunction : Enzymes of unknown specificity. | Nicotinate dehydrogenase subunit A; Subunit of the two-component enzyme NicAB that mediates nicotinate hydroxylation, the first step in the aerobic nicotinate degradation pathway. Mediates conversion of nicotinate into 6- hydroxynicotinate (6HNA). | 0.853 |
| PP_3361 | nicB | PP_3361 | PP_3948 | Putative aminotransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Unknownfunction : Enzymes of unknown specificity. | Nicotinate dehydrogenase subunit B; Subunit of the two-component enzyme NicAB that mediates nicotinate hydroxylation, the first step in the aerobic nicotinate degradation pathway. Mediates conversion of nicotinate into 6- hydroxynicotinate (6HNA). | 0.767 |
| PP_3361 | nicC | PP_3361 | PP_3944 | Putative aminotransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Unknownfunction : Enzymes of unknown specificity. | 6-hydroxynicotinate 3-monooxygenase; Flavin-dependent monooxygenase (FMO) that catalyzes the decarboxylative hydroxylation of 6-hydroxynicotinic acid (6-HNA) to 2,5-dihydroxypyridine (2,5-DHP) with concomitant oxidation of NADH, a step in the aerobic nicotinate degradation pathway. Belongs to the 6-hydroxynicotinate 3-monooxygenase family. | 0.775 |
| PP_3361 | nicT | PP_3361 | PP_3940 | Putative aminotransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Unknownfunction : Enzymes of unknown specificity. | Putative metabolite transport protein NicT; Probable transporter, possibly involved in the aerobic nicotinate degradation pathway. | 0.864 |
| PP_3622 | nicA | PP_3622 | PP_3947 | Putative Isoquinoline 1-oxidoreductase, beta subunit; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. | Nicotinate dehydrogenase subunit A; Subunit of the two-component enzyme NicAB that mediates nicotinate hydroxylation, the first step in the aerobic nicotinate degradation pathway. Mediates conversion of nicotinate into 6- hydroxynicotinate (6HNA). | 0.933 |
| PP_4234 | nicA | PP_4234 | PP_3947 | Aldehyde oxidase and xanthine dehydrogenase. | Nicotinate dehydrogenase subunit A; Subunit of the two-component enzyme NicAB that mediates nicotinate hydroxylation, the first step in the aerobic nicotinate degradation pathway. Mediates conversion of nicotinate into 6- hydroxynicotinate (6HNA). | 0.861 |
| PP_4234 | xdhB | PP_4234 | PP_4279 | Aldehyde oxidase and xanthine dehydrogenase. | Xanthine dehydrogenase subunit XdhB; Function experimentally demonstrated in the studied species; enzyme; Fattyacidandphospholipidmetabolism : Degradation. | 0.554 |
| nicA | PP_2478 | PP_3947 | PP_2478 | Nicotinate dehydrogenase subunit A; Subunit of the two-component enzyme NicAB that mediates nicotinate hydroxylation, the first step in the aerobic nicotinate degradation pathway. Mediates conversion of nicotinate into 6- hydroxynicotinate (6HNA). | Putative Isoquinoline 1-oxidoreductase, beta subunit; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. | 0.960 |
| nicA | PP_3361 | PP_3947 | PP_3361 | Nicotinate dehydrogenase subunit A; Subunit of the two-component enzyme NicAB that mediates nicotinate hydroxylation, the first step in the aerobic nicotinate degradation pathway. Mediates conversion of nicotinate into 6- hydroxynicotinate (6HNA). | Putative aminotransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Unknownfunction : Enzymes of unknown specificity. | 0.853 |
| nicA | PP_3622 | PP_3947 | PP_3622 | Nicotinate dehydrogenase subunit A; Subunit of the two-component enzyme NicAB that mediates nicotinate hydroxylation, the first step in the aerobic nicotinate degradation pathway. Mediates conversion of nicotinate into 6- hydroxynicotinate (6HNA). | Putative Isoquinoline 1-oxidoreductase, beta subunit; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. | 0.933 |
| nicA | PP_4234 | PP_3947 | PP_4234 | Nicotinate dehydrogenase subunit A; Subunit of the two-component enzyme NicAB that mediates nicotinate hydroxylation, the first step in the aerobic nicotinate degradation pathway. Mediates conversion of nicotinate into 6- hydroxynicotinate (6HNA). | Aldehyde oxidase and xanthine dehydrogenase. | 0.861 |
| nicA | nicB | PP_3947 | PP_3948 | Nicotinate dehydrogenase subunit A; Subunit of the two-component enzyme NicAB that mediates nicotinate hydroxylation, the first step in the aerobic nicotinate degradation pathway. Mediates conversion of nicotinate into 6- hydroxynicotinate (6HNA). | Nicotinate dehydrogenase subunit B; Subunit of the two-component enzyme NicAB that mediates nicotinate hydroxylation, the first step in the aerobic nicotinate degradation pathway. Mediates conversion of nicotinate into 6- hydroxynicotinate (6HNA). | 0.999 |
| nicA | nicC | PP_3947 | PP_3944 | Nicotinate dehydrogenase subunit A; Subunit of the two-component enzyme NicAB that mediates nicotinate hydroxylation, the first step in the aerobic nicotinate degradation pathway. Mediates conversion of nicotinate into 6- hydroxynicotinate (6HNA). | 6-hydroxynicotinate 3-monooxygenase; Flavin-dependent monooxygenase (FMO) that catalyzes the decarboxylative hydroxylation of 6-hydroxynicotinic acid (6-HNA) to 2,5-dihydroxypyridine (2,5-DHP) with concomitant oxidation of NADH, a step in the aerobic nicotinate degradation pathway. Belongs to the 6-hydroxynicotinate 3-monooxygenase family. | 0.989 |
| nicA | nicT | PP_3947 | PP_3940 | Nicotinate dehydrogenase subunit A; Subunit of the two-component enzyme NicAB that mediates nicotinate hydroxylation, the first step in the aerobic nicotinate degradation pathway. Mediates conversion of nicotinate into 6- hydroxynicotinate (6HNA). | Putative metabolite transport protein NicT; Probable transporter, possibly involved in the aerobic nicotinate degradation pathway. | 0.864 |
| nicA | paoC | PP_3947 | PP_3310 | Nicotinate dehydrogenase subunit A; Subunit of the two-component enzyme NicAB that mediates nicotinate hydroxylation, the first step in the aerobic nicotinate degradation pathway. Mediates conversion of nicotinate into 6- hydroxynicotinate (6HNA). | Promiscuous aromatic aldehyde dehydrogenase, molybdopterin-binding subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.987 |
| nicA | pncB | PP_3947 | PP_4868 | Nicotinate dehydrogenase subunit A; Subunit of the two-component enzyme NicAB that mediates nicotinate hydroxylation, the first step in the aerobic nicotinate degradation pathway. Mediates conversion of nicotinate into 6- hydroxynicotinate (6HNA). | Nicotinate phosphoribosyltransferase; Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP; Belongs to the NAPRTase family. | 0.901 |
| nicA | xdhB | PP_3947 | PP_4279 | Nicotinate dehydrogenase subunit A; Subunit of the two-component enzyme NicAB that mediates nicotinate hydroxylation, the first step in the aerobic nicotinate degradation pathway. Mediates conversion of nicotinate into 6- hydroxynicotinate (6HNA). | Xanthine dehydrogenase subunit XdhB; Function experimentally demonstrated in the studied species; enzyme; Fattyacidandphospholipidmetabolism : Degradation. | 0.958 |
| nicB | PP_3361 | PP_3948 | PP_3361 | Nicotinate dehydrogenase subunit B; Subunit of the two-component enzyme NicAB that mediates nicotinate hydroxylation, the first step in the aerobic nicotinate degradation pathway. Mediates conversion of nicotinate into 6- hydroxynicotinate (6HNA). | Putative aminotransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Unknownfunction : Enzymes of unknown specificity. | 0.767 |
| nicB | nicA | PP_3948 | PP_3947 | Nicotinate dehydrogenase subunit B; Subunit of the two-component enzyme NicAB that mediates nicotinate hydroxylation, the first step in the aerobic nicotinate degradation pathway. Mediates conversion of nicotinate into 6- hydroxynicotinate (6HNA). | Nicotinate dehydrogenase subunit A; Subunit of the two-component enzyme NicAB that mediates nicotinate hydroxylation, the first step in the aerobic nicotinate degradation pathway. Mediates conversion of nicotinate into 6- hydroxynicotinate (6HNA). | 0.999 |