node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
cobA | cobG | PP_2090 | PP_4829 | Uroporphyrinogen-III C-methyltransferase; Belongs to the precorrin methyltransferase family. | Putative precorrin-3B synthase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Biosynthesis of cofactors, prosthetic groups, and carriers. | 0.890 |
cobA | cobI | PP_2090 | PP_4827 | Uroporphyrinogen-III C-methyltransferase; Belongs to the precorrin methyltransferase family. | Precorrin-2 C(20)-methyltransferase; Methylates precorrin-2 at the C-20 position to produce precorrin-3A. | 0.937 |
cobA | cysD | PP_2090 | PP_1303 | Uroporphyrinogen-III C-methyltransferase; Belongs to the precorrin methyltransferase family. | Sulfate adenylyltransferase subunit 2. | 0.694 |
cobA | cysG | PP_2090 | PP_3999 | Uroporphyrinogen-III C-methyltransferase; Belongs to the precorrin methyltransferase family. | Uroporphyrinogen-III C-methyltransferase/Precorrin-2 dehydrogenase/Sirohydrochlorin ferrochelatase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | 0.962 |
cobA | cysH | PP_2090 | PP_2328 | Uroporphyrinogen-III C-methyltransferase; Belongs to the precorrin methyltransferase family. | Phosphoadenosine phosphosulfate reductase; Reduction of activated sulfate into sulfite. | 0.807 |
cobA | cysI | PP_2090 | PP_2371 | Uroporphyrinogen-III C-methyltransferase; Belongs to the precorrin methyltransferase family. | Sulphite reductase hemoprotein, beta subunit. | 0.761 |
cobA | cysNC | PP_2090 | PP_1304 | Uroporphyrinogen-III C-methyltransferase; Belongs to the precorrin methyltransferase family. | Sulfate adenylyltransferase subunit 1/adenylyl-sulfate kinase; May be the GTPase, regulating ATP sulfurylase activity. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN/NodQ subfamily. | 0.808 |
cobA | hemC | PP_2090 | PP_0186 | Uroporphyrinogen-III C-methyltransferase; Belongs to the precorrin methyltransferase family. | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.988 |
cobA | hemD | PP_2090 | PP_0187 | Uroporphyrinogen-III C-methyltransferase; Belongs to the precorrin methyltransferase family. | Uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | 0.927 |
cobA | hemE | PP_2090 | PP_5074 | Uroporphyrinogen-III C-methyltransferase; Belongs to the precorrin methyltransferase family. | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | 0.923 |
cobG | cobA | PP_4829 | PP_2090 | Putative precorrin-3B synthase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Biosynthesis of cofactors, prosthetic groups, and carriers. | Uroporphyrinogen-III C-methyltransferase; Belongs to the precorrin methyltransferase family. | 0.890 |
cobG | cobI | PP_4829 | PP_4827 | Putative precorrin-3B synthase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Biosynthesis of cofactors, prosthetic groups, and carriers. | Precorrin-2 C(20)-methyltransferase; Methylates precorrin-2 at the C-20 position to produce precorrin-3A. | 0.991 |
cobG | cysD | PP_4829 | PP_1303 | Putative precorrin-3B synthase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Biosynthesis of cofactors, prosthetic groups, and carriers. | Sulfate adenylyltransferase subunit 2. | 0.789 |
cobG | cysG | PP_4829 | PP_3999 | Putative precorrin-3B synthase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Biosynthesis of cofactors, prosthetic groups, and carriers. | Uroporphyrinogen-III C-methyltransferase/Precorrin-2 dehydrogenase/Sirohydrochlorin ferrochelatase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | 0.923 |
cobG | cysH | PP_4829 | PP_2328 | Putative precorrin-3B synthase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Biosynthesis of cofactors, prosthetic groups, and carriers. | Phosphoadenosine phosphosulfate reductase; Reduction of activated sulfate into sulfite. | 0.872 |
cobG | cysNC | PP_4829 | PP_1304 | Putative precorrin-3B synthase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Biosynthesis of cofactors, prosthetic groups, and carriers. | Sulfate adenylyltransferase subunit 1/adenylyl-sulfate kinase; May be the GTPase, regulating ATP sulfurylase activity. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN/NodQ subfamily. | 0.961 |
cobI | cobA | PP_4827 | PP_2090 | Precorrin-2 C(20)-methyltransferase; Methylates precorrin-2 at the C-20 position to produce precorrin-3A. | Uroporphyrinogen-III C-methyltransferase; Belongs to the precorrin methyltransferase family. | 0.937 |
cobI | cobG | PP_4827 | PP_4829 | Precorrin-2 C(20)-methyltransferase; Methylates precorrin-2 at the C-20 position to produce precorrin-3A. | Putative precorrin-3B synthase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Biosynthesis of cofactors, prosthetic groups, and carriers. | 0.991 |
cobI | cysG | PP_4827 | PP_3999 | Precorrin-2 C(20)-methyltransferase; Methylates precorrin-2 at the C-20 position to produce precorrin-3A. | Uroporphyrinogen-III C-methyltransferase/Precorrin-2 dehydrogenase/Sirohydrochlorin ferrochelatase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | 0.957 |
cysD | cobA | PP_1303 | PP_2090 | Sulfate adenylyltransferase subunit 2. | Uroporphyrinogen-III C-methyltransferase; Belongs to the precorrin methyltransferase family. | 0.694 |