| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| PP_4040 | rutR | PP_4040 | PP_4039 | Putative enzyme of the glyoxalase family; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Transcriptional regulator, TetR family; Function of strongly homologous gene; regulator; Regulatory functions. | 0.531 |
| PP_4289 | rutR | PP_4289 | PP_4039 | Homologs of previously reported genes of unknown function. | Transcriptional regulator, TetR family; Function of strongly homologous gene; regulator; Regulatory functions. | 0.461 |
| betI | rutR | PP_5719 | PP_4039 | Choline-responsive transcriptional repressor BetI; Repressor involved in choline regulation of the bet genes. | Transcriptional regulator, TetR family; Function of strongly homologous gene; regulator; Regulatory functions. | 0.483 |
| glcC | nrdR | PP_3744 | PP_0513 | Transcriptional dual regulator GlcC-Glycolate; Function of homologous gene experimentally demonstrated in an other organism; regulator; Energy metabolism. | DNA-binding transcriptional repressor NrdR-Zn2+-ATP/dATP; Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes; Belongs to the NrdR family. | 0.523 |
| glcC | rutR | PP_3744 | PP_4039 | Transcriptional dual regulator GlcC-Glycolate; Function of homologous gene experimentally demonstrated in an other organism; regulator; Energy metabolism. | Transcriptional regulator, TetR family; Function of strongly homologous gene; regulator; Regulatory functions. | 0.653 |
| glcC | sahR | PP_3744 | PP_4966 | Transcriptional dual regulator GlcC-Glycolate; Function of homologous gene experimentally demonstrated in an other organism; regulator; Energy metabolism. | Transcriptional regulator of methionine metabolism; Function of homologous gene experimentally demonstrated in an other organism; regulator. | 0.740 |
| nrdR | glcC | PP_0513 | PP_3744 | DNA-binding transcriptional repressor NrdR-Zn2+-ATP/dATP; Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes; Belongs to the NrdR family. | Transcriptional dual regulator GlcC-Glycolate; Function of homologous gene experimentally demonstrated in an other organism; regulator; Energy metabolism. | 0.523 |
| nrdR | rutR | PP_0513 | PP_4039 | DNA-binding transcriptional repressor NrdR-Zn2+-ATP/dATP; Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes; Belongs to the NrdR family. | Transcriptional regulator, TetR family; Function of strongly homologous gene; regulator; Regulatory functions. | 0.506 |
| nrdR | sahR | PP_0513 | PP_4966 | DNA-binding transcriptional repressor NrdR-Zn2+-ATP/dATP; Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes; Belongs to the NrdR family. | Transcriptional regulator of methionine metabolism; Function of homologous gene experimentally demonstrated in an other organism; regulator. | 0.531 |
| pdhR | rutR | PP_4734 | PP_4039 | DNA-binding transcriptional dual regulator, LldR-L-lactate; Function experimentally demonstrated in the studied genus; regulator; Energymetabolism : Aerobic. | Transcriptional regulator, TetR family; Function of strongly homologous gene; regulator; Regulatory functions. | 0.443 |
| pdhR | sahR | PP_4734 | PP_4966 | DNA-binding transcriptional dual regulator, LldR-L-lactate; Function experimentally demonstrated in the studied genus; regulator; Energymetabolism : Aerobic. | Transcriptional regulator of methionine metabolism; Function of homologous gene experimentally demonstrated in an other organism; regulator. | 0.500 |
| pydA | pydB | PP_4038 | PP_4036 | NADP-dependent dihydropyrimidine dehydrogenase subunit PreA; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Central intermediary metabolism. | D-hydantoinase/dihydropyrimidinase; Function experimentally demonstrated in the studied genus; enzyme; Fattyacidandphospholipidmetabolism : Degradation. | 0.999 |
| pydA | pydX | PP_4038 | PP_4037 | NADP-dependent dihydropyrimidine dehydrogenase subunit PreA; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Central intermediary metabolism. | NADP-dependent dihydropyrimidine dehydrogenase subunit; Function of strongly homologous gene; enzyme; Fattyacidandphospholipidmetabolism : Degradation. | 0.999 |
| pydA | rutR | PP_4038 | PP_4039 | NADP-dependent dihydropyrimidine dehydrogenase subunit PreA; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Central intermediary metabolism. | Transcriptional regulator, TetR family; Function of strongly homologous gene; regulator; Regulatory functions. | 0.878 |
| pydB | pydA | PP_4036 | PP_4038 | D-hydantoinase/dihydropyrimidinase; Function experimentally demonstrated in the studied genus; enzyme; Fattyacidandphospholipidmetabolism : Degradation. | NADP-dependent dihydropyrimidine dehydrogenase subunit PreA; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Central intermediary metabolism. | 0.999 |
| pydB | pydX | PP_4036 | PP_4037 | D-hydantoinase/dihydropyrimidinase; Function experimentally demonstrated in the studied genus; enzyme; Fattyacidandphospholipidmetabolism : Degradation. | NADP-dependent dihydropyrimidine dehydrogenase subunit; Function of strongly homologous gene; enzyme; Fattyacidandphospholipidmetabolism : Degradation. | 0.998 |
| pydB | rutR | PP_4036 | PP_4039 | D-hydantoinase/dihydropyrimidinase; Function experimentally demonstrated in the studied genus; enzyme; Fattyacidandphospholipidmetabolism : Degradation. | Transcriptional regulator, TetR family; Function of strongly homologous gene; regulator; Regulatory functions. | 0.936 |
| pydX | pydA | PP_4037 | PP_4038 | NADP-dependent dihydropyrimidine dehydrogenase subunit; Function of strongly homologous gene; enzyme; Fattyacidandphospholipidmetabolism : Degradation. | NADP-dependent dihydropyrimidine dehydrogenase subunit PreA; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Central intermediary metabolism. | 0.999 |
| pydX | pydB | PP_4037 | PP_4036 | NADP-dependent dihydropyrimidine dehydrogenase subunit; Function of strongly homologous gene; enzyme; Fattyacidandphospholipidmetabolism : Degradation. | D-hydantoinase/dihydropyrimidinase; Function experimentally demonstrated in the studied genus; enzyme; Fattyacidandphospholipidmetabolism : Degradation. | 0.998 |
| pydX | rutR | PP_4037 | PP_4039 | NADP-dependent dihydropyrimidine dehydrogenase subunit; Function of strongly homologous gene; enzyme; Fattyacidandphospholipidmetabolism : Degradation. | Transcriptional regulator, TetR family; Function of strongly homologous gene; regulator; Regulatory functions. | 0.878 |