Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
mltDMembrane-bound lytic murein transglycosylase D. (476 aa)    
Predicted Functional Partners:
PP_4143
Homologs of previously reported genes of unknown function.
 
   
 0.751
gloB
Hydroxyacylglutathione hydrolase; Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl- glutathione to form glutathione and D-lactic acid.
       0.745
mltF
Membrane-bound lytic murein transglycosylase F; Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella. In the N-terminal section; belongs to the bacterial solute- binding protein 3 family.
 
   
 0.721
PP_4146
Peptide ABC transporter, periplamic peptide-binding protein.
     
 0.701
PP_4149
Putative inner membrane ABC transporter permease protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative transporter; Transport and binding proteins.
       0.697
yejF
Microcin C transporter - ATP binding subunit; Function of homologous gene experimentally demonstrated in an other organism; transporter; Transport and binding proteins; Belongs to the ABC transporter superfamily.
       0.697
rlpA
RlpA-like lipoprotein; Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides.
  
  
 0.687
rnhA
Ribonuclease H; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
  
    0.681
yceG
Septation protein; Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation.
 
  
 0.680
rlpA-2
Putative Lipoprotein; Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides.
  
  
 0.658
Your Current Organism:
Pseudomonas putida KT2440
NCBI taxonomy Id: 160488
Other names: P. putida KT2440, Pseudomonas putida (strain KT2440), Pseudomonas putida str. KT2440
Server load: low (12%) [HD]