Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
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[Homology]
Score
hemNOxygen-independent coproporphyrinogen III dehydrogenase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Biosynthesisofcofactors,prostheticgroups,andcarriers : Heme, porphyrin, and cobalamin; Belongs to the anaerobic coproporphyrinogen-III oxidase family. (460 aa)    
Predicted Functional Partners:
hemF
Coproporphyrinogen-III oxidase, aerobic; Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen- IX.
    
 0.983
hemE
Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
 
 
 0.961
PP_0431
Homologs of previously reported genes of unknown function.
    
 0.915
oprG
Outer membrane protein OprG.
 
  
 0.831
ccoN-II
Cytochrome c oxidase subunit I, cbb3-type; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the heme-copper respiratory oxidase family.
 
  
 0.823
ccoN-I
Cytochrome c oxidase subunit I, cbb3-type; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the heme-copper respiratory oxidase family.
 
  
 0.805
PP_4259
Iron-sulfur cluster-binding protein.
 
  
 0.805
ccoO-II
Cytochrome c oxidase subunit, cbb3-type; Function of strongly homologous gene; enzyme.
 
  
 0.788
ccoO-I
Cytochrome c oxidase subunit, cbb3-type; Function of strongly homologous gene; enzyme.
 
  
 0.777
fnrA
DNA-binding transcriptional dual regulator; Function experimentally demonstrated in the studied strain; regulator; Energymetabolism : Anaerobic.
 
  
 0.755
Your Current Organism:
Pseudomonas putida KT2440
NCBI taxonomy Id: 160488
Other names: P. putida KT2440, Pseudomonas putida (strain KT2440), Pseudomonas putida str. KT2440
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