STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
phhBPterin-4-alpha-carbinolamine dehydratase; Involved in tetrahydrobiopterin biosynthesis. Seems to both prevent the formation of 7-pterins and accelerate the formation of quinonoid-BH2. May also have a positive regulatory role in the expression of phhA (By similarity); Belongs to the pterin-4-alpha-carbinolamine dehydratase family. (118 aa)    
Predicted Functional Partners:
phhA
Phenylalanine-4-hydroxylase; Function experimentally demonstrated in the studied strain; enzyme; Fattyacidandphospholipidmetabolism : Degradation.
 
 0.999
phhR
Sigma-54 dependent transcriptional regulator; Function experimentally demonstrated in the studied strain; regulator; Fattyacidandphospholipidmetabolism : Degradation.
  
  
 0.897
hpd
4-hydroxyphenylpyruvate dioxygenase; Function experimentally demonstrated in the studied strain; enzyme; Energymetabolism : Amino acids and amines.
  
  
 0.877
hmgB
Fumarylacetoacetase; Function experimentally demonstrated in the studied species; enzyme; Energy metabolism.
  
  
 0.850
hmgC
Maleylacetoacetate isomerase; Function experimentally demonstrated in the studied species; enzyme; Energy metabolism.
  
  
 0.845
tyrB
Aromatic-amino-acid aminotransferase; Function experimentally demonstrated in the studied strain; enzyme; Aminoacidbiosynthesis : Aspartate family.
  
  
 0.817
PP_2552
DOPA decarboxylase.
    
 
 0.779
hmgA
Homogentisate 1,2-dioxygenase; Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the ar omatic ring of 2,5-dihydroxyphenylacetate to yield maleylacetoacetate.
  
  
 0.765
ppiB
Peptidyl-prolyl cis-trans isomerase B (rotamase B); PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family.
   
  
 0.749
PP_3654
Leucine-responsive regulatory protein; Function of homologous gene experimentally demonstrated in an other organism; regulator.
     
 0.651
Your Current Organism:
Pseudomonas putida KT2440
NCBI taxonomy Id: 160488
Other names: P. putida KT2440, Pseudomonas putida (strain KT2440), Pseudomonas putida str. KT2440
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