node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
PP_0747 | guaA | PP_0747 | PP_1032 | Hypoxanthine-guanine phosphoribosyltransferase. | Glutamine-hydrolyzing GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.952 |
PP_0747 | guaB | PP_0747 | PP_1031 | Hypoxanthine-guanine phosphoribosyltransferase. | IMP dehydrogenase and single strand DNA binding factor; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.976 |
PP_0747 | purA | PP_0747 | PP_4889 | Hypoxanthine-guanine phosphoribosyltransferase. | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.948 |
PP_0747 | purH | PP_0747 | PP_4822 | Hypoxanthine-guanine phosphoribosyltransferase. | Phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Purines,pyrimidines,nucleosides,andnucleotides : Purine ribonucleotide biosynthesis. | 0.949 |
PP_0747 | purL | PP_0747 | PP_1037 | Hypoxanthine-guanine phosphoribosyltransferase. | Phosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. | 0.589 |
argG | asnB | PP_1088 | PP_1750 | Argininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 1 subfamily. | Asparagine synthetase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.928 |
argG | purA | PP_1088 | PP_4889 | Argininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 1 subfamily. | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.942 |
argG | purL | PP_1088 | PP_1037 | Argininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 1 subfamily. | Phosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. | 0.631 |
argG | pyrB | PP_1088 | PP_4998 | Argininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 1 subfamily. | Aspartate carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. | 0.911 |
asnB | argG | PP_1750 | PP_1088 | Asparagine synthetase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | Argininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 1 subfamily. | 0.928 |
asnB | guaA | PP_1750 | PP_1032 | Asparagine synthetase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | Glutamine-hydrolyzing GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.527 |
asnB | prs | PP_1750 | PP_0722 | Asparagine synthetase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. | 0.501 |
asnB | purA | PP_1750 | PP_4889 | Asparagine synthetase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.935 |
asnB | purL | PP_1750 | PP_1037 | Asparagine synthetase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | Phosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. | 0.541 |
asnB | pyrB | PP_1750 | PP_4998 | Asparagine synthetase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | Aspartate carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. | 0.934 |
guaA | PP_0747 | PP_1032 | PP_0747 | Glutamine-hydrolyzing GMP synthase; Catalyzes the synthesis of GMP from XMP. | Hypoxanthine-guanine phosphoribosyltransferase. | 0.952 |
guaA | asnB | PP_1032 | PP_1750 | Glutamine-hydrolyzing GMP synthase; Catalyzes the synthesis of GMP from XMP. | Asparagine synthetase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.527 |
guaA | guaB | PP_1032 | PP_1031 | Glutamine-hydrolyzing GMP synthase; Catalyzes the synthesis of GMP from XMP. | IMP dehydrogenase and single strand DNA binding factor; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.999 |
guaA | prs | PP_1032 | PP_0722 | Glutamine-hydrolyzing GMP synthase; Catalyzes the synthesis of GMP from XMP. | Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. | 0.815 |
guaA | purA | PP_1032 | PP_4889 | Glutamine-hydrolyzing GMP synthase; Catalyzes the synthesis of GMP from XMP. | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.959 |