Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
sahRTranscriptional regulator of methionine metabolism; Function of homologous gene experimentally demonstrated in an other organism; regulator. (330 aa)    
Predicted Functional Partners:
metK
Methionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
  
  
 0.895
PP_3582
RND efflux transporter, outer membrane protein.
      
 0.722
tktA
Transketolase A; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.
     
 0.721
PP_4987
Putative Chemotaxis protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology.
  
     0.688
ligB
DNA ligase B; Catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. Belongs to the NAD-dependent DNA ligase family. LigB subfamily.
     
 0.686
ahcY
Adenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.
 
   
 0.676
metE
5-methyltetrahydropteroyltriglutamate- homocysteine methyltransferase.
     
 0.674
glcC
Transcriptional dual regulator GlcC-Glycolate; Function of homologous gene experimentally demonstrated in an other organism; regulator; Energy metabolism.
   
  
 0.664
epd
D-erythrose 4-phosphate dehydrogenase; Catalyzes the NAD-dependent conversion of D-erythrose 4- phosphate to 4-phosphoerythronate.
     
 0.657
PP_0288
Putative Oxalate/formate antiporter; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology.
     
 0.648
Your Current Organism:
Pseudomonas putida KT2440
NCBI taxonomy Id: 160488
Other names: P. putida KT2440, Pseudomonas putida (strain KT2440), Pseudomonas putida str. KT2440
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