PP_5002 protein (Pseudomonas putida KT2440) - STRING interaction network

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Score

PP_5002

Homologs of previously reported genes of unknown function. (125 aa)

Predicted Functional Partners:

mrp

0.877

hslU

0.801

hslV

0.775

thrB

0.558

phaA

0.524

phaB

0.508

lon-I

0.488

PP_5086

0.488

rpmE

0.488

priA

0.488

Your Current Organism:

Pseudomonas putida KT2440

NCBI taxonomy Id: 160488
Other names: P. putida KT2440, Pseudomonas putida (strain KT2440), Pseudomonas putida str. KT2440

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
PP_5002	PP_5086	PP_5002	PP_5086	Homologs of previously reported genes of unknown function.	Putative nuclease (SNase domain protein); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme.	0.488
PP_5002	hslU	PP_5002	PP_5001	Homologs of previously reported genes of unknown function.	Protease HslVU, ATPase component; ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis.	0.801
PP_5002	hslV	PP_5002	PP_5000	Homologs of previously reported genes of unknown function.	Peptidase component of the ATP-dependent HslVU protease; Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery.	0.775
PP_5002	lon-I	PP_5002	PP_1443	Homologs of previously reported genes of unknown function.	DNA-binding, ATP-dependent protease; ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.	0.488
PP_5002	mrp	PP_5002	PP_1098	Homologs of previously reported genes of unknown function.	ATP-dependent Fe-S cluster transferase; Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP; Belongs to the Mrp/NBP35 ATP-binding proteins family.	0.877
PP_5002	phaA	PP_5002	PP_5003	Homologs of previously reported genes of unknown function.	Poly(3-hydroxyalkanoate) polymerase 1; Function of homologous gene experimentally demonstrated in an other organism; enzyme.	0.524
PP_5002	phaB	PP_5002	PP_5004	Homologs of previously reported genes of unknown function.	Poly(3-hydroxyalkanoate) depolymerase.	0.508
PP_5002	priA	PP_5002	PP_5088	Homologs of previously reported genes of unknown function.	Primosome assembly protein; Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily.	0.488
PP_5002	rpmE	PP_5002	PP_5087	Homologs of previously reported genes of unknown function.	Ribosomal protein L31; Binds the 23S rRNA.	0.488
PP_5002	thrB	PP_5002	PP_0121	Homologs of previously reported genes of unknown function.	Homoserine kinase; Function experimentally demonstrated in the studied genus; enzyme; Belongs to the pseudomonas-type ThrB family.	0.558
PP_5086	PP_5002	PP_5086	PP_5002	Putative nuclease (SNase domain protein); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme.	Homologs of previously reported genes of unknown function.	0.488
PP_5086	hslU	PP_5086	PP_5001	Putative nuclease (SNase domain protein); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme.	Protease HslVU, ATPase component; ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis.	0.488
PP_5086	hslV	PP_5086	PP_5000	Putative nuclease (SNase domain protein); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme.	Peptidase component of the ATP-dependent HslVU protease; Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery.	0.488
PP_5086	priA	PP_5086	PP_5088	Putative nuclease (SNase domain protein); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme.	Primosome assembly protein; Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily.	0.701
PP_5086	rpmE	PP_5086	PP_5087	Putative nuclease (SNase domain protein); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme.	Ribosomal protein L31; Binds the 23S rRNA.	0.797
hslU	PP_5002	PP_5001	PP_5002	Protease HslVU, ATPase component; ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis.	Homologs of previously reported genes of unknown function.	0.801
hslU	PP_5086	PP_5001	PP_5086	Protease HslVU, ATPase component; ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis.	Putative nuclease (SNase domain protein); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme.	0.488
hslU	hslV	PP_5001	PP_5000	Protease HslVU, ATPase component; ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis.	Peptidase component of the ATP-dependent HslVU protease; Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery.	0.999
hslU	lon-I	PP_5001	PP_1443	Protease HslVU, ATPase component; ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis.	DNA-binding, ATP-dependent protease; ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.	0.848
hslU	phaB	PP_5001	PP_5004	Protease HslVU, ATPase component; ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis.	Poly(3-hydroxyalkanoate) depolymerase.	0.428