Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
PP_5099Homologs of previously reported genes of unknown function. (144 aa)    
Predicted Functional Partners:
metW
Methionine biosynthesis protein MetW; Function experimentally demonstrated in the studied strain; enzyme.
     0.954
rdgB
dITP/XTP pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family.
  
    0.948
yggW
Coproporphyrinogen/heterocyclic compound oxidase (aerobic); Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family.
  
    0.871
PP_5102
Conserved hypothetical protein; Homologs of previously reported genes of unknown function.
  
    0.864
metX
Homoserine O-acetyltransferase; Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine; Belongs to the AB hydrolase superfamily. MetX family.
       0.833
PP_5096
Putative factor involved in shape determination; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative membrane component.
 
     0.771
PP_5094
Putative enzyme with PLP binding domain; Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis; Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.
  
    0.684
PP_0279
Homologs of previously reported genes of unknown function.
  
     0.631
PP_5267
Putative cytochrome c5; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative carrier; Energy metabolism.
  
    0.619
PP_4260
Homologs of previously reported genes of unknown function.
  
    0.607
Your Current Organism:
Pseudomonas putida KT2440
NCBI taxonomy Id: 160488
Other names: P. putida KT2440, Pseudomonas putida (strain KT2440), Pseudomonas putida str. KT2440
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