Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
PP_5126Conserved protein of unknown function containing an HDOD domain; Homologs of previously reported genes of unknown function; Unknown function. (290 aa)    
Predicted Functional Partners:
PP_3453
Putative Sensor protein RstB; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology.
    
 
 0.874
mutM
Formamidopyrimidine-DNA glycosylase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
  
    0.825
PP_1422
Homologs of previously reported genes of unknown function.
  
     0.771
PP_0408
Homologs of previously reported genes of unknown function.
  
     0.736
fleS
Sensory box histidine kinase FleS.
  
   0.729
PP_3698
Homologs of previously reported genes of unknown function.
      
 0.713
PP_5395
Homologs of previously reported genes of unknown function.
      
 0.713
PP_2942
Response regulator.
 
     0.712
PP_4363
Sensor histidine kinase/response regulator.
 
     0.706
PP_4333
CheW domain protein.
 
    0.692
Your Current Organism:
Pseudomonas putida KT2440
NCBI taxonomy Id: 160488
Other names: P. putida KT2440, Pseudomonas putida (strain KT2440), Pseudomonas putida str. KT2440
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