| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| XF_0868 | XF_1121 | XF_0868 | XF_1121 | Dihydrolipoamide dehydrogenase; Similar to GI|1073212 (percent identity: 57 %/query alignment coverage: 100.2 %/subject alignment coverage: 101.7 %); identified by sequence similarity; putative; ORF located using Glimmer/RBSfinder. | 5,10-methylenetetrahydrofolate reductase; Similar to SP|O67422 (percent identity: 37 %/query alignment coverage: 99.6 %/subject alignment coverage: 92.6 %); identified by sequence similarity; putative; ORF located using Glimmer/RBSfinder; Belongs to the methylenetetrahydrofolate reductase family. | 0.419 |
| XF_0868 | XF_1548 | XF_0868 | XF_1548 | Dihydrolipoamide dehydrogenase; Similar to GI|1073212 (percent identity: 57 %/query alignment coverage: 100.2 %/subject alignment coverage: 101.7 %); identified by sequence similarity; putative; ORF located using Glimmer/RBSfinder. | Dihydrolipoamide dehydrogenase; Similar to SP|P14218 (percent identity: 58 %/query alignment coverage: 97.6 %/subject alignment coverage: 100.0 %); identified by sequence similarity; putative; ORF located using Glimmer/RBSfinder. | 0.990 |
| XF_0868 | folD | XF_0868 | XF_2431 | Dihydrolipoamide dehydrogenase; Similar to GI|1073212 (percent identity: 57 %/query alignment coverage: 100.2 %/subject alignment coverage: 101.7 %); identified by sequence similarity; putative; ORF located using Glimmer/RBSfinder. | Bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.422 |
| XF_0868 | gcvH | XF_0868 | XF_0181 | Dihydrolipoamide dehydrogenase; Similar to GI|1073212 (percent identity: 57 %/query alignment coverage: 100.2 %/subject alignment coverage: 101.7 %); identified by sequence similarity; putative; ORF located using Glimmer/RBSfinder. | Glycine cleavage H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.994 |
| XF_0868 | gcvP | XF_0868 | XF_1385 | Dihydrolipoamide dehydrogenase; Similar to GI|1073212 (percent identity: 57 %/query alignment coverage: 100.2 %/subject alignment coverage: 101.7 %); identified by sequence similarity; putative; ORF located using Glimmer/RBSfinder. | Glycine decarboxylase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.982 |
| XF_0868 | gcvT | XF_0868 | XF_0183 | Dihydrolipoamide dehydrogenase; Similar to GI|1073212 (percent identity: 57 %/query alignment coverage: 100.2 %/subject alignment coverage: 101.7 %); identified by sequence similarity; putative; ORF located using Glimmer/RBSfinder. | Glycine cleavage T protein; The glycine cleavage system catalyzes the degradation of glycine. | 0.992 |
| XF_0868 | glyA | XF_0868 | XF_0946 | Dihydrolipoamide dehydrogenase; Similar to GI|1073212 (percent identity: 57 %/query alignment coverage: 100.2 %/subject alignment coverage: 101.7 %); identified by sequence similarity; putative; ORF located using Glimmer/RBSfinder. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.950 |
| XF_1121 | XF_0868 | XF_1121 | XF_0868 | 5,10-methylenetetrahydrofolate reductase; Similar to SP|O67422 (percent identity: 37 %/query alignment coverage: 99.6 %/subject alignment coverage: 92.6 %); identified by sequence similarity; putative; ORF located using Glimmer/RBSfinder; Belongs to the methylenetetrahydrofolate reductase family. | Dihydrolipoamide dehydrogenase; Similar to GI|1073212 (percent identity: 57 %/query alignment coverage: 100.2 %/subject alignment coverage: 101.7 %); identified by sequence similarity; putative; ORF located using Glimmer/RBSfinder. | 0.419 |
| XF_1121 | folD | XF_1121 | XF_2431 | 5,10-methylenetetrahydrofolate reductase; Similar to SP|O67422 (percent identity: 37 %/query alignment coverage: 99.6 %/subject alignment coverage: 92.6 %); identified by sequence similarity; putative; ORF located using Glimmer/RBSfinder; Belongs to the methylenetetrahydrofolate reductase family. | Bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.933 |
| XF_1121 | gcvH | XF_1121 | XF_0181 | 5,10-methylenetetrahydrofolate reductase; Similar to SP|O67422 (percent identity: 37 %/query alignment coverage: 99.6 %/subject alignment coverage: 92.6 %); identified by sequence similarity; putative; ORF located using Glimmer/RBSfinder; Belongs to the methylenetetrahydrofolate reductase family. | Glycine cleavage H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.668 |
| XF_1121 | gcvP | XF_1121 | XF_1385 | 5,10-methylenetetrahydrofolate reductase; Similar to SP|O67422 (percent identity: 37 %/query alignment coverage: 99.6 %/subject alignment coverage: 92.6 %); identified by sequence similarity; putative; ORF located using Glimmer/RBSfinder; Belongs to the methylenetetrahydrofolate reductase family. | Glycine decarboxylase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.479 |
| XF_1121 | gcvT | XF_1121 | XF_0183 | 5,10-methylenetetrahydrofolate reductase; Similar to SP|O67422 (percent identity: 37 %/query alignment coverage: 99.6 %/subject alignment coverage: 92.6 %); identified by sequence similarity; putative; ORF located using Glimmer/RBSfinder; Belongs to the methylenetetrahydrofolate reductase family. | Glycine cleavage T protein; The glycine cleavage system catalyzes the degradation of glycine. | 0.934 |
| XF_1121 | glyA | XF_1121 | XF_0946 | 5,10-methylenetetrahydrofolate reductase; Similar to SP|O67422 (percent identity: 37 %/query alignment coverage: 99.6 %/subject alignment coverage: 92.6 %); identified by sequence similarity; putative; ORF located using Glimmer/RBSfinder; Belongs to the methylenetetrahydrofolate reductase family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.943 |
| XF_1548 | XF_0868 | XF_1548 | XF_0868 | Dihydrolipoamide dehydrogenase; Similar to SP|P14218 (percent identity: 58 %/query alignment coverage: 97.6 %/subject alignment coverage: 100.0 %); identified by sequence similarity; putative; ORF located using Glimmer/RBSfinder. | Dihydrolipoamide dehydrogenase; Similar to GI|1073212 (percent identity: 57 %/query alignment coverage: 100.2 %/subject alignment coverage: 101.7 %); identified by sequence similarity; putative; ORF located using Glimmer/RBSfinder. | 0.990 |
| XF_1548 | gcvH | XF_1548 | XF_0181 | Dihydrolipoamide dehydrogenase; Similar to SP|P14218 (percent identity: 58 %/query alignment coverage: 97.6 %/subject alignment coverage: 100.0 %); identified by sequence similarity; putative; ORF located using Glimmer/RBSfinder. | Glycine cleavage H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.985 |
| XF_1548 | gcvP | XF_1548 | XF_1385 | Dihydrolipoamide dehydrogenase; Similar to SP|P14218 (percent identity: 58 %/query alignment coverage: 97.6 %/subject alignment coverage: 100.0 %); identified by sequence similarity; putative; ORF located using Glimmer/RBSfinder. | Glycine decarboxylase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.943 |
| XF_1548 | gcvT | XF_1548 | XF_0183 | Dihydrolipoamide dehydrogenase; Similar to SP|P14218 (percent identity: 58 %/query alignment coverage: 97.6 %/subject alignment coverage: 100.0 %); identified by sequence similarity; putative; ORF located using Glimmer/RBSfinder. | Glycine cleavage T protein; The glycine cleavage system catalyzes the degradation of glycine. | 0.953 |
| XF_1548 | glyA | XF_1548 | XF_0946 | Dihydrolipoamide dehydrogenase; Similar to SP|P14218 (percent identity: 58 %/query alignment coverage: 97.6 %/subject alignment coverage: 100.0 %); identified by sequence similarity; putative; ORF located using Glimmer/RBSfinder. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.913 |
| fmt | folD | XF_0927 | XF_2431 | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | Bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.972 |
| fmt | gcvP | XF_0927 | XF_1385 | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | Glycine decarboxylase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.654 |