| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| XF_0397 | parC | XF_0397 | XF_1353 | Hypothetical protein; identified by sequence similarity; putative; ORF located using Glimmer/RBSfinder. | Topoisomerase IV subunit; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule; Belongs to the type II topoisomerase GyrA/ParC subunit family. ParC type 1 subfamily. | 0.469 |
| XF_2244 | lolB | XF_2244 | XF_2646 | Signal peptidase I; Similar to SP|P00803 (percent identity: 40 %/query alignment coverage: 113.5 %/subject alignment coverage: 93.2 %); identified by sequence similarity; putative; ORF located using Glimmer/RBSfinder; Belongs to the peptidase S26 family. | Outer membrane lipoprotein precursor; Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein. | 0.443 |
| XF_2244 | metG | XF_2244 | XF_0549 | Signal peptidase I; Similar to SP|P00803 (percent identity: 40 %/query alignment coverage: 113.5 %/subject alignment coverage: 93.2 %); identified by sequence similarity; putative; ORF located using Glimmer/RBSfinder; Belongs to the peptidase S26 family. | methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. | 0.430 |
| XF_2244 | minE | XF_2244 | XF_1320 | Signal peptidase I; Similar to SP|P00803 (percent identity: 40 %/query alignment coverage: 113.5 %/subject alignment coverage: 93.2 %); identified by sequence similarity; putative; ORF located using Glimmer/RBSfinder; Belongs to the peptidase S26 family. | Cell division topological specificity factor; Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity). | 0.585 |
| XF_2244 | parC | XF_2244 | XF_1353 | Signal peptidase I; Similar to SP|P00803 (percent identity: 40 %/query alignment coverage: 113.5 %/subject alignment coverage: 93.2 %); identified by sequence similarity; putative; ORF located using Glimmer/RBSfinder; Belongs to the peptidase S26 family. | Topoisomerase IV subunit; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule; Belongs to the type II topoisomerase GyrA/ParC subunit family. ParC type 1 subfamily. | 0.608 |
| gyrB | metG | XF_0005 | XF_0549 | DNA gyrase subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. | 0.558 |
| gyrB | parC | XF_0005 | XF_1353 | DNA gyrase subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | Topoisomerase IV subunit; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule; Belongs to the type II topoisomerase GyrA/ParC subunit family. ParC type 1 subfamily. | 0.986 |
| gyrB | topA | XF_0005 | XF_0920 | DNA gyrase subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] | 0.430 |
| lolB | XF_2244 | XF_2646 | XF_2244 | Outer membrane lipoprotein precursor; Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein. | Signal peptidase I; Similar to SP|P00803 (percent identity: 40 %/query alignment coverage: 113.5 %/subject alignment coverage: 93.2 %); identified by sequence similarity; putative; ORF located using Glimmer/RBSfinder; Belongs to the peptidase S26 family. | 0.443 |
| lolB | minE | XF_2646 | XF_1320 | Outer membrane lipoprotein precursor; Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein. | Cell division topological specificity factor; Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity). | 0.618 |
| lolB | parC | XF_2646 | XF_1353 | Outer membrane lipoprotein precursor; Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein. | Topoisomerase IV subunit; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule; Belongs to the type II topoisomerase GyrA/ParC subunit family. ParC type 1 subfamily. | 0.582 |
| metG | XF_2244 | XF_0549 | XF_2244 | methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. | Signal peptidase I; Similar to SP|P00803 (percent identity: 40 %/query alignment coverage: 113.5 %/subject alignment coverage: 93.2 %); identified by sequence similarity; putative; ORF located using Glimmer/RBSfinder; Belongs to the peptidase S26 family. | 0.430 |
| metG | gyrB | XF_0549 | XF_0005 | methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. | DNA gyrase subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | 0.558 |
| metG | parC | XF_0549 | XF_1353 | methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. | Topoisomerase IV subunit; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule; Belongs to the type II topoisomerase GyrA/ParC subunit family. ParC type 1 subfamily. | 0.702 |
| metG | parE | XF_0549 | XF_1286 | methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. | Topoisomerase IV subunit B; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule; Belongs to the type II topoisomerase family. ParE type 1 subfamily. | 0.582 |
| metG | phoU | XF_0549 | XF_2145 | methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. | Phosphate regulon transcriptional regulator; Plays a role in the regulation of phosphate uptake. | 0.421 |
| minE | XF_2244 | XF_1320 | XF_2244 | Cell division topological specificity factor; Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity). | Signal peptidase I; Similar to SP|P00803 (percent identity: 40 %/query alignment coverage: 113.5 %/subject alignment coverage: 93.2 %); identified by sequence similarity; putative; ORF located using Glimmer/RBSfinder; Belongs to the peptidase S26 family. | 0.585 |
| minE | lolB | XF_1320 | XF_2646 | Cell division topological specificity factor; Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity). | Outer membrane lipoprotein precursor; Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein. | 0.618 |
| minE | parC | XF_1320 | XF_1353 | Cell division topological specificity factor; Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity). | Topoisomerase IV subunit; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule; Belongs to the type II topoisomerase GyrA/ParC subunit family. ParC type 1 subfamily. | 0.811 |
| minE | phoU | XF_1320 | XF_2145 | Cell division topological specificity factor; Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity). | Phosphate regulon transcriptional regulator; Plays a role in the regulation of phosphate uptake. | 0.405 |