STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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hisHAmidotransferase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF (By similarity). (200 aa)    
Predicted Functional Partners:
hisI
phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase bifunctional enzyme; Similar to SP|O24714 (percent identity: 56 %/query alignment coverage: 93.7 %/subject alignment coverage: 97.5 %); identified by sequence similarity; putative; ORF located using Glimmer/RBSfinder; In the C-terminal section; belongs to the PRA-PH family.
 
  
 0.999
hisF
Cyclase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity).
 0.999
hisA
Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Similar to SP|P10371 (percent identity: 44 %/query alignment coverage: 90.2 %/subject alignment coverage: 97.6 %); identified by sequence similarity; putative; ORF located using Glimmer/RBSfinder.
 
 
 0.999
hisB
Imidazoleglycerolphosphate dehydratase/histidinol-phosphate phosphatase bifunctional enzyme; Similar to SP|P06987 (percent identity: 50 %/query alignment coverage: 99.2 %/subject alignment coverage: 104.8 %); identified by sequence similarity; putative; ORF located using Glimmer/RBSfinder; In the N-terminal section; belongs to the histidinol- phosphatase family.
 
 
 0.999
hisC
Histidinol-phosphate aminotransferase; Similar to SP|P06986 (percent identity: 42 %/query alignment coverage: 97.8 %/subject alignment coverage: 100.3 %); identified by sequence similarity; putative; ORF located using Glimmer/RBSfinder; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
 
  
 0.997
hisD
Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine.
 
  
 0.997
hisG
ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
 
  
 0.997
purH
Bifunctional purine biosynthesis protein; Similar to SP|P15639 (percent identity: 59 %/query alignment coverage: 91.3 %/subject alignment coverage: 99.1 %); identified by sequence similarity; putative; ORF located using Glimmer/RBSfinder.
    
 0.839
XF_2221
Conserved hypothetical protein; Similar to GI|2465565 (percent identity: 37 %/query alignment coverage: 72.3 %/subject alignment coverage: 77.9 %); identified by sequence similarity; putative; ORF located using Glimmer/RBSfinder.
 
     0.838
XF_1553
Adenylosuccinate lyase; Similar to SP|P44797 (percent identity: 57 %/query alignment coverage: 83.8 %/subject alignment coverage: 97.8 %); identified by sequence similarity; putative; ORF located using Glimmer/RBSfinder; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
    
  0.807
Your Current Organism:
Xylella fastidiosa
NCBI taxonomy Id: 160492
Other names: X. fastidiosa 9a5c, Xylella fastidiosa 9a5c
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