Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
hisShistidyl-tRNA synthetase; Similar to GI|4155714 (percent identity: 36 %/query alignment coverage: 95.1 %/subject alignment coverage: 100.2 %); identified by sequence similarity; putative; ORF located using Glimmer/RBSfinder. (466 aa)    
Predicted Functional Partners:
aspS
aspartyl-tRNA synthetase; Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp- AMP and then transferred to the acceptor end of tRNA(Asp). Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
 
  
 0.894
XF_0463
Hypothetical protein; identified by sequence similarity; putative; ORF located using Glimmer/RBSfinder.
  
    0.844
hisG
ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
  
 
 0.812
metG
methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
 
 
 0.790
cysS
cysteinyl-tRNA synthetase; Similar to SP|P43816 (percent identity: 46 %/query alignment coverage: 98.7 %/subject alignment coverage: 102.0 %); identified by sequence similarity; putative; ORF located using Glimmer/RBSfinder; Belongs to the class-I aminoacyl-tRNA synthetase family.
  
 
 0.750
thrS
threonyl-tRNA synthetase; Catalyzes the attachment of threonine to tRNA(Thr) in a two- step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged L-seryl-tRNA(Thr).
  
 
 0.725
valS
valyl-tRNA synthetase; Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA- dependent manner; Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.
  
 
 0.707
leuS
leucyl-tRNA synthetase; Similar to SP|P07813 (percent identity: 58 %/query alignment coverage: 98.3 %/subject alignment coverage: 101.4 %); identified by sequence similarity; putative; ORF located using Glimmer/RBSfinder; Belongs to the class-I aminoacyl-tRNA synthetase family.
  
 
 0.681
hisI
phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase bifunctional enzyme; Similar to SP|O24714 (percent identity: 56 %/query alignment coverage: 93.7 %/subject alignment coverage: 97.5 %); identified by sequence similarity; putative; ORF located using Glimmer/RBSfinder; In the C-terminal section; belongs to the PRA-PH family.
  
  
 0.679
ispG
Conserved hypothetical protein; Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME- 2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. Belongs to the IspG family.
  
  
 0.672
Your Current Organism:
Xylella fastidiosa
NCBI taxonomy Id: 160492
Other names: X. fastidiosa 9a5c, Xylella fastidiosa 9a5c
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