STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
ispGConserved hypothetical protein; Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME- 2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. Belongs to the IspG family. (417 aa)    
Predicted Functional Partners:
ispH
Drug tolerance protein; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Belongs to the IspH family.
 
  
 0.977
ispF
Conserved hypothetical protein; Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2- C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).
 
  
 0.974
XF_2574
Conserved hypothetical protein; Similar to GI|6459110 (percent identity: 38 %/query alignment coverage: 89.4 %/subject alignment coverage: 78.1 %); identified by sequence similarity; putative; ORF located using Glimmer/RBSfinder.
       0.806
dxr
1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family.
 
  
 0.766
ispD
Conserved hypothetical protein; Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D- erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).
 
   
 0.705
ispE
Isopentenyl monophosphate kinase; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.
  
  
 0.694
hisS
histidyl-tRNA synthetase; Similar to GI|4155714 (percent identity: 36 %/query alignment coverage: 95.1 %/subject alignment coverage: 100.2 %); identified by sequence similarity; putative; ORF located using Glimmer/RBSfinder.
  
  
 0.672
dxs
Deoxyxylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily.
 
   
 0.672
XF_2576
Hypothetical protein; identified by sequence similarity; putative; ORF located using Glimmer/RBSfinder.
       0.642
XF_2577
Two-component system, sensor protein; Similar to GI|703269 (percent identity: 25 %/query alignment coverage: 104.2 %/subject alignment coverage: 97.5 %); identified by sequence similarity; putative; ORF located using Glimmer/RBSfinder.
   
   0.495
Your Current Organism:
Xylella fastidiosa
NCBI taxonomy Id: 160492
Other names: X. fastidiosa 9a5c, Xylella fastidiosa 9a5c
Server load: low (34%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.