STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
smgHypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the Smg family. (158 aa)    
Predicted Functional Partners:
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
 
   
 0.904
AOV18674.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
     0.902
AOV18198.1
DNA protecting protein DprA; Derived by automated computational analysis using gene prediction method: Protein Homology.
     
 0.895
AOV18201.1
threonylcarbamoyl-AMP synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.
       0.842
hemF
Coproporphyrinogen III oxidase; Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen- IX.
       0.836
aroE
Shikimate dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
       0.792
AOV18194.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.
 
    0.752
zapD
Hypothetical protein; Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity.
  
     0.746
def
Peptide deformylase; Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.
       0.701
AOV18193.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
    0.699
Your Current Organism:
Acidihalobacter prosperus
NCBI taxonomy Id: 160660
Other names: A. prosperus, DSM 5130, JCM 30709, Thiobacillus prosperus
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.