msrA protein (Confluentimicrobium sp. EMB200NS6)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

msrA

Peptide methionine sulfoxide reductase; Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine. (221 aa)

Predicted Functional Partners:

ALG89850.1

0.989

ALG90093.1

0.989

polA

0.848

ALG90521.1

0.832

ALG91298.1

0.832

ALG89300.1

0.828

ALG91555.1

0.531

ALG89203.1

0.512

ALG88886.1

0.491

ALG89443.1

0.452

Your Current Organism:

Confluentimicrobium sp. EMB200NS6

NCBI taxonomy Id: 1609966
Other names: C. sp. EMB200-NS6, Confluentimicrobium sp. EMB200-NS6

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ALG88886.1	msrA	TQ29_00265	TQ29_00260	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Peptide methionine sulfoxide reductase; Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.	0.491
ALG89203.1	ALG89300.1	TQ29_02200	TQ29_02805	Dihydrolipoamide dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Redox-active disulfide protein 2; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.518
ALG89203.1	ALG90521.1	TQ29_02200	TQ29_10370	Dihydrolipoamide dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Thiol:disulfide interchange protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.518
ALG89203.1	ALG91298.1	TQ29_02200	TQ29_15210	Dihydrolipoamide dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.518
ALG89203.1	msrA	TQ29_02200	TQ29_00260	Dihydrolipoamide dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Peptide methionine sulfoxide reductase; Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.	0.512
ALG89300.1	ALG89203.1	TQ29_02805	TQ29_02200	Redox-active disulfide protein 2; Derived by automated computational analysis using gene prediction method: Protein Homology.	Dihydrolipoamide dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.518
ALG89300.1	ALG89850.1	TQ29_02805	TQ29_06125	Redox-active disulfide protein 2; Derived by automated computational analysis using gene prediction method: Protein Homology.	Methionine sulfoxide reductase B; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.489
ALG89300.1	ALG90093.1	TQ29_02805	TQ29_07710	Redox-active disulfide protein 2; Derived by automated computational analysis using gene prediction method: Protein Homology.	Methionine sulfoxide reductase B; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the MsrB Met sulfoxide reductase family.	0.489
ALG89300.1	msrA	TQ29_02805	TQ29_00260	Redox-active disulfide protein 2; Derived by automated computational analysis using gene prediction method: Protein Homology.	Peptide methionine sulfoxide reductase; Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.	0.828
ALG89443.1	msrA	TQ29_03650	TQ29_00260	Peptidylprolyl isomerase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Peptide methionine sulfoxide reductase; Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.	0.452
ALG89850.1	ALG89300.1	TQ29_06125	TQ29_02805	Methionine sulfoxide reductase B; Derived by automated computational analysis using gene prediction method: Protein Homology.	Redox-active disulfide protein 2; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.489
ALG89850.1	ALG90521.1	TQ29_06125	TQ29_10370	Methionine sulfoxide reductase B; Derived by automated computational analysis using gene prediction method: Protein Homology.	Thiol:disulfide interchange protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.500
ALG89850.1	ALG91298.1	TQ29_06125	TQ29_15210	Methionine sulfoxide reductase B; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.500
ALG89850.1	msrA	TQ29_06125	TQ29_00260	Methionine sulfoxide reductase B; Derived by automated computational analysis using gene prediction method: Protein Homology.	Peptide methionine sulfoxide reductase; Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.	0.989
ALG90093.1	ALG89300.1	TQ29_07710	TQ29_02805	Methionine sulfoxide reductase B; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the MsrB Met sulfoxide reductase family.	Redox-active disulfide protein 2; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.489
ALG90093.1	ALG90521.1	TQ29_07710	TQ29_10370	Methionine sulfoxide reductase B; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the MsrB Met sulfoxide reductase family.	Thiol:disulfide interchange protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.500
ALG90093.1	ALG91298.1	TQ29_07710	TQ29_15210	Methionine sulfoxide reductase B; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the MsrB Met sulfoxide reductase family.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.500
ALG90093.1	msrA	TQ29_07710	TQ29_00260	Methionine sulfoxide reductase B; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the MsrB Met sulfoxide reductase family.	Peptide methionine sulfoxide reductase; Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.	0.989
ALG90521.1	ALG89203.1	TQ29_10370	TQ29_02200	Thiol:disulfide interchange protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Dihydrolipoamide dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.518
ALG90521.1	ALG89850.1	TQ29_10370	TQ29_06125	Thiol:disulfide interchange protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Methionine sulfoxide reductase B; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.500

page 1 of 2

Network Stats

number of nodes:

11

number of edges:

47

average node degree:

8.55

avg. local clustering coefficient:

0.968

expected number of edges:

10

PPI enrichment p-value:

1.11e-16

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0045039

Protein insertion into mitochondrial inner membrane

3 of 7

3.0

2.53

2.54e-05

GO:0046834

Lipid phosphorylation

2 of 2

3.37

1.79

0.00060

GO:0046512

Sphingosine biosynthetic process

2 of 5

2.97

1.59

0.0013

GO:0006121

Mitochondrial electron transport, succinate to ubiquinone

2 of 6

2.89

1.59

0.0013

GO:0006099

Tricarboxylic acid cycle

2 of 29

2.2

1.05

0.0111

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0140318

Protein transporter activity

3 of 25

2.44

1.87

0.00032

GO:0004402

Histone acetyltransferase activity

2 of 23

2.3

0.85

0.0274

GO:0140110

Transcription regulator activity

4 of 412

1.35

0.78

0.0171

GO:0046872

Metal ion binding

6 of 2233

0.79

0.46

0.0331

GO:0005488

Binding

10 of 7866

0.47

0.32

0.0274

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0042721

TIM22 mitochondrial import inner membrane insertion complex

3 of 4

3.24

3.32

9.53e-07

GO:0098800

Inner mitochondrial membrane protein complex

5 of 120

1.99

2.79

9.53e-07

GO:0042719

Mitochondrial intermembrane space protein transporter complex

2 of 3

3.19

2.13

0.00014

GO:0005749

Mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)

2 of 5

2.97

1.98

0.00026

GO:0032991

Protein-containing complex

6 of 2897

0.68

0.45

0.0164

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:24142

Tim10-like, and TIM22 mitochondrial import inner membrane insertion complex

3 of 7

3.0

2.59

1.96e-05

CL:19911

Fumarate reductase complex

2 of 5

2.97

1.48

0.0021

CL:1544

Mixed, incl. Lectin, and Met-10+ like-protein

2 of 11

2.63

1.31

0.0040

CL:21436

Sphingolipid metabolism

2 of 18

2.41

1.12

0.0088

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00020

Citrate cycle (TCA cycle)

2 of 49

1.98

0.79

0.0330

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-1268020

Mitochondrial protein import

3 of 72

1.99

1.25

0.0037

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0042719

Mitochondrial intermembrane space protein transporter complex

2 of 4

3.06

1.6

0.0013

GOCC:0045281

Succinate dehydrogenase complex

2 of 7

2.82

1.52

0.0017

GOCC:0098798

Mitochondrial protein complex

4 of 184

1.7

1.42

0.00090

GOCC:0005740

Mitochondrial envelope

4 of 367

1.4

1.12

0.0019

GOCC:0098800

Inner mitochondrial membrane protein complex

2 of 75

1.79

0.82

0.0255

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0811

Translocation

2 of 13

2.55

1.41

0.0026

KW-0496

Mitochondrion

3 of 102

1.83

1.28

0.0026

KW-1015

Disulfide bond

2 of 92

1.7

0.7

0.0428

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF02953

Tim10/DDP family zinc finger

2 of 4

3.06

1.41

0.0029

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR034804

Fumarate reductase/succinate dehydrogenase, transmembrane subunit

2 of 3

3.19

1.39

0.0032

IPR001206

Diacylglycerol kinase, catalytic domain

2 of 2

3.37

1.39

0.0032

IPR035427

Tim10-like domain superfamily

2 of 4

3.06

1.38

0.0032

IPR017438

Inorganic polyphosphate/ATP-NAD kinase, N-terminal

2 of 5

2.97

1.38

0.0032

IPR016064

NAD kinase/diacylglycerol kinase-like domain superfamily

2 of 5

2.97

1.38

0.0032

(more ...)

Enrichment display settings

Enrichment analysis is still ongoing, please wait ...

Server load: low (18%) [HD]

Permalink

Network

Neighborhood

Experiments

Fusion

Databases

Cooccurrence

Textmining

Coexpression

© STRING Consortium 2024

Credits

Access

Info

About