ALG90104.1 protein (Confluentimicrobium sp. EMB200NS6)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

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Coexpression

Experiments

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[Homology]

Score

ALG90104.1

Multidrug MFS transporter; Derived by automated computational analysis using gene prediction method: Protein Homology. (408 aa)

Predicted Functional Partners:

ALG90103.1

0.774

ALG91863.1

0.551

ALG90105.1

0.523

ALG92034.1

0.426

Your Current Organism:

Confluentimicrobium sp. EMB200NS6

NCBI taxonomy Id: 1609966
Other names: C. sp. EMB200-NS6, Confluentimicrobium sp. EMB200-NS6

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ALG90103.1	ALG90104.1	TQ29_07765	TQ29_07770	Acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Multidrug MFS transporter; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.774
ALG90103.1	ALG90105.1	TQ29_07765	TQ29_07780	Acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Phospholipase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.522
ALG90103.1	ALG91863.1	TQ29_07765	TQ29_07775	Acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	3-methyladenine DNA glycosylase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.522
ALG90104.1	ALG90103.1	TQ29_07770	TQ29_07765	Multidrug MFS transporter; Derived by automated computational analysis using gene prediction method: Protein Homology.	Acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.774
ALG90104.1	ALG90105.1	TQ29_07770	TQ29_07780	Multidrug MFS transporter; Derived by automated computational analysis using gene prediction method: Protein Homology.	Phospholipase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.523
ALG90104.1	ALG91863.1	TQ29_07770	TQ29_07775	Multidrug MFS transporter; Derived by automated computational analysis using gene prediction method: Protein Homology.	3-methyladenine DNA glycosylase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.551
ALG90104.1	ALG92034.1	TQ29_07770	TQ29_15375	Multidrug MFS transporter; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.426
ALG90105.1	ALG90103.1	TQ29_07780	TQ29_07765	Phospholipase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.522
ALG90105.1	ALG90104.1	TQ29_07780	TQ29_07770	Phospholipase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Multidrug MFS transporter; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.523
ALG90105.1	ALG91863.1	TQ29_07780	TQ29_07775	Phospholipase; Derived by automated computational analysis using gene prediction method: Protein Homology.	3-methyladenine DNA glycosylase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.965
ALG91863.1	ALG90103.1	TQ29_07775	TQ29_07765	3-methyladenine DNA glycosylase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.522
ALG91863.1	ALG90104.1	TQ29_07775	TQ29_07770	3-methyladenine DNA glycosylase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Multidrug MFS transporter; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.551
ALG91863.1	ALG90105.1	TQ29_07775	TQ29_07780	3-methyladenine DNA glycosylase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Phospholipase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.965
ALG92034.1	ALG90104.1	TQ29_15375	TQ29_07770	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Multidrug MFS transporter; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.426

Network Stats

number of nodes:

11

number of edges:

55

average node degree:

10

avg. local clustering coefficient:

1

expected number of edges:

32

PPI enrichment p-value:

4.87e-05

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0009097

Isoleucine biosynthetic process

8 of 19

2.07

4.9

2.25e-12

GO:0009099

Valine biosynthetic process

7 of 14

2.14

4.78

1.81e-11

GO:1901607

Alpha-amino acid biosynthetic process

9 of 97

1.41

2.39

4.47e-10

GO:0019752

Carboxylic acid metabolic process

10 of 313

0.95

1.08

1.47e-07

GO:1901564

Organonitrogen compound metabolic process

10 of 738

0.58

0.48

0.00039

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003984

Acetolactate synthase activity

5 of 9

2.19

3.29

1.81e-07

GO:0030976

Thiamine pyrophosphate binding

5 of 10

2.14

3.25

1.81e-07

GO:0000287

Magnesium ion binding

7 of 54

1.56

2.33

1.81e-07

GO:0019842

Vitamin binding

6 of 67

1.4

1.73

6.00e-06

GO:0050660

Flavin adenine dinucleotide binding

4 of 37

1.48

1.31

0.00072

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005948

Acetolactate synthase complex

4 of 4

2.44

3.19

7.38e-07

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:265

Valine, leucine and isoleucine biosynthesis

8 of 19

2.07

4.98

1.25e-12

CL:268

Valine, leucine and isoleucine biosynthesis

7 of 14

2.14

4.8

1.67e-11

CL:270

Branched-chain amino acid biosynthesis

4 of 8

2.14

2.69

3.66e-06

CL:261

Alpha-amino acid metabolic process, and Glycine, serine and threonine metabolism

9 of 84

1.47

2.64

1.28e-10

CL:77

Mixed, incl. Microbial metabolism in diverse environments, and Valine, leucine and isoleucine biosynthesis

10 of 176

1.2

1.76

7.07e-10

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00290

Valine, leucine and isoleucine biosynthesis

8 of 20

2.05

5.11

2.98e-13

map00770

Pantothenate and CoA biosynthesis

7 of 28

1.84

3.74

1.62e-10

map00660

C5-Branched dibasic acid metabolism

5 of 11

2.1

3.61

1.67e-08

map00650

Butanoate metabolism

6 of 32

1.72

2.91

1.73e-08

map01210

2-Oxocarboxylic acid metabolism

7 of 46

1.63

2.87

2.73e-09

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005948

Acetolactate synthase complex

5 of 9

2.19

3.4

9.96e-08

GOCC:1902494

Catalytic complex

6 of 183

0.96

0.78

0.0015

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0100

Branched-chain amino acid biosynthesis

5 of 12

2.06

3.11

2.41e-07

KW-0786

Thiamine pyrophosphate

3 of 6

2.14

1.92

0.00018

KW-0028

Amino-acid biosynthesis

6 of 68

1.39

1.71

6.54e-06

KW-0460

Magnesium

5 of 95

1.17

1.04

0.00064

KW-0479

Metal-binding

6 of 236

0.85

0.65

0.0029

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF02775

Thiamine pyrophosphate enzyme, C-terminal TPP binding domain

5 of 9

2.19

3.26

2.13e-07

PF00205

Thiamine pyrophosphate enzyme, central domain

4 of 4

2.44

3.02

1.65e-06

PF02776

Thiamine pyrophosphate enzyme, N-terminal TPP binding domain

3 of 3

2.44

2.09

0.00012

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR011766

Thiamine pyrophosphate enzyme, TPP-binding

5 of 9

2.19

3.08

5.48e-07

IPR045229

Thiamine pyrophosphate enzyme

4 of 4

2.44

2.91

2.82e-06

IPR012000

Thiamine pyrophosphate enzyme, central domain

4 of 4

2.44

2.91

2.82e-06

IPR029061

Thiamin diphosphate-binding fold

5 of 15

1.97

2.64

2.10e-06

IPR029035

DHS-like NAD/FAD-binding domain superfamily

4 of 10

2.05

2.27

2.39e-05

(more ...)

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