STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
secEUnannotated protein; Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation. (58 aa)    
Predicted Functional Partners:
secG
Unannotated protein; Involved in protein export. Participates in an early event of protein translocation; Belongs to the SecG family.
  
 0.999
secY
Unannotated protein; The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.
  
 0.999
secA
Unannotated protein; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.
    
 0.996
ffh
Unannotated protein; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Belongs to the GTP-binding SRP family. SRP54 subfamily.
  
 0.991
ftsY
Unannotated protein; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).
    
 0.990
yidC
Unannotated protein; Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins; Belongs to the OXA1/ALB3/YidC family. Type 2 subfamily.
   
 0.982
nusG
Unannotated protein; Participates in transcription elongation, termination and antitermination.
  
  
 0.975
GCA_002119645_00320
Unannotated protein.
 
 
 0.974
rplK
Unannotated protein; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
  
 
 0.962
rplA
Unannotated protein; Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.
  
 
 0.953
Your Current Organism:
Lactobacillus fermentum
NCBI taxonomy Id: 1613
Other names: ATCC 14931, Bacillus casei d, Bacillus d, CCUG 30138, CIP 102980, IFO 15885, L. fermentum, LMG 6902, LMG:6902, Lactobacillus cellobiosus, Lactobacillus sp. NCIM 2165, Lactobacterium fermentum, NBRC 15885, NCCB 46038, NCIMB 11840, NRRL B-4524
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.