GAT64993.1 protein (Planomonospora sphaerica)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

Experiments

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[Homology]

Score

GAT64993.1

FBP domain-containing protein. (167 aa)

Predicted Functional Partners:

GAT64994.1

0.762

GAT69110.1

0.470

GAT64992.1

0.449

GAT69109.1

0.447

GAT67090.1

0.423

GAT67272.1

0.402

Your Current Organism:

Planomonospora sphaerica

NCBI taxonomy Id: 161355
Other names: ATCC 51587, DSM 44632, JCM 9374, NRRL 18923, P. sphaerica, strain A51460

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
GAT64992.1	GAT64993.1	PS9374_00624	PS9374_00625	ATPase.	FBP domain-containing protein.	0.449
GAT64993.1	GAT64992.1	PS9374_00625	PS9374_00624	FBP domain-containing protein.	ATPase.	0.449
GAT64993.1	GAT64994.1	PS9374_00625	PS9374_00626	FBP domain-containing protein.	tetR family transcriptional regulator.	0.762
GAT64993.1	GAT67090.1	PS9374_00625	PS9374_02743	FBP domain-containing protein.	mRNA interferase PemK.	0.423
GAT64993.1	GAT67272.1	PS9374_00625	PS9374_02925	FBP domain-containing protein.	tetR family transcriptional regulator.	0.402
GAT64993.1	GAT69109.1	PS9374_00625	PS9374_04779	FBP domain-containing protein.	marR family transcriptional regulator.	0.447
GAT64993.1	GAT69110.1	PS9374_00625	PS9374_04780	FBP domain-containing protein.	DUF4098 domain-containing protein.	0.470
GAT64994.1	GAT64993.1	PS9374_00626	PS9374_00625	tetR family transcriptional regulator.	FBP domain-containing protein.	0.762
GAT67090.1	GAT64993.1	PS9374_02743	PS9374_00625	mRNA interferase PemK.	FBP domain-containing protein.	0.423
GAT67272.1	GAT64993.1	PS9374_02925	PS9374_00625	tetR family transcriptional regulator.	FBP domain-containing protein.	0.402
GAT69109.1	GAT64993.1	PS9374_04779	PS9374_00625	marR family transcriptional regulator.	FBP domain-containing protein.	0.447
GAT69109.1	GAT69110.1	PS9374_04779	PS9374_04780	marR family transcriptional regulator.	DUF4098 domain-containing protein.	0.904
GAT69110.1	GAT64993.1	PS9374_04780	PS9374_00625	DUF4098 domain-containing protein.	FBP domain-containing protein.	0.470
GAT69110.1	GAT69109.1	PS9374_04780	PS9374_04779	DUF4098 domain-containing protein.	marR family transcriptional regulator.	0.904

Network Stats

number of nodes:

11

number of edges:

43

average node degree:

7.82

avg. local clustering coefficient:

0.86

expected number of edges:

25

PPI enrichment p-value:

0.0007

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006281

DNA repair

5 of 55

1.32

1.1

0.0014

GO:0006259

DNA metabolic process

7 of 154

1.02

0.86

0.0011

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0140097

Catalytic activity, acting on DNA

7 of 98

1.21

1.32

3.09e-05

GO:0008094

ATP-dependent activity, acting on DNA

4 of 41

1.35

0.99

0.0041

GO:0003677

DNA binding

8 of 255

0.86

0.74

0.00047

GO:0140664

ATP-dependent DNA damage sensor activity

2 of 6

1.88

0.69

0.0493

GO:0008408

3-5 exonuclease activity

2 of 7

1.82

0.68

0.0493

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:627

Mixed, incl. Mismatch repair, and DNA-templated DNA replication

9 of 39

1.72

3.72

4.28e-12

CL:678

SOS response, and Mutator protein

5 of 12

1.98

2.95

3.60e-07

CL:633

DNA-directed DNA polymerase, and HRDC domain

4 of 5

2.26

2.86

2.24e-06

CL:680

Holliday junction helicase complex, and DNA recombination and repair protein RecA-like, ATP-binding domain

3 of 6

2.06

1.78

0.00031

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03420

Nucleotide excision repair

4 of 18

1.71

1.7

0.00016

map03430

Mismatch repair

4 of 25

1.56

1.52

0.00025

map03440

Homologous recombination

3 of 42

1.21

0.65

0.0302

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0044815

DNA packaging complex

3 of 13

1.72

1.02

0.0089

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0234

DNA repair

5 of 31

1.57

1.85

2.09e-05

KW-0227

DNA damage

5 of 31

1.57

1.85

2.09e-05

KW-0235

DNA replication

3 of 17

1.61

1.16

0.0032

KW-0238

DNA-binding

8 of 180

1.01

1.04

2.09e-05

KW-0239

DNA-directed DNA polymerase

2 of 6

1.88

0.9

0.0183

(more ...)

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