STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
GAT66580.1Low-complexity protein. (434 aa)    
Predicted Functional Partners:
gyrB
DNA gyrase subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
    
 
 0.914
GAT69476.1
Serine/threonine protein kinase.
 
  
  0.579
GAT68289.1
DNA topoisomerase IV subunit B.
    
 
 0.574
GAT66581.1
Beta-galactosidase.
       0.539
GAT71367.1
Pentapeptide repeat-containing protein.
  
     0.525
GAT68179.1
Pentapeptide repeat-containing protein.
  
     0.490
GAT70536.1
Adenylate cyclase family 3 protein.
  
  
  0.487
GAT65347.1
Transcriptional regulator.
  
  
  0.479
GAT67648.1
ECF subfamily RNA polymerase sigma-24.
  
   0.432
GAT69096.1
Signal transduction histidine kinase.
  
 0.424
Your Current Organism:
Planomonospora sphaerica
NCBI taxonomy Id: 161355
Other names: ATCC 51587, DSM 44632, JCM 9374, NRRL 18923, P. sphaerica, strain A51460
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.