STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
GAT67559.1Acetolactate synthase. (579 aa)    
Predicted Functional Partners:
ilvC
Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
 
 
 0.999
GAT67558.1
Acetolactate synthase.
 0.999
GAT67545.1
3-isopropylmalate dehydrogenase.
 0.987
ilvD
Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family.
 
 0.974
GAT67541.1
Citramalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family.
 
 
 0.954
GAT69598.1
Threonine dehydratase.
 
 0.949
GAT66161.1
2-oxoacid:ferredoxin oxidoreductase subunit beta.
  
 
 0.940
GAT65027.1
Threonine dehydratase.
 
 0.939
leuC
Isopropylmalate isomerase; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate.
 
 
 0.933
GAT66162.1
2-oxoglutarate ferredoxin oxidoreductase subunit alpha.
  
 
 0.932
Your Current Organism:
Planomonospora sphaerica
NCBI taxonomy Id: 161355
Other names: ATCC 51587, DSM 44632, JCM 9374, NRRL 18923, P. sphaerica, strain A51460
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.