STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ALO42614.1(P)ppGpp synthetase I/GTP pyrophosphokinase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. (718 aa)    
Predicted Functional Partners:
ALO42613.1
Nucleoside triphosphate pyrophosphohydrolase, non-specific; Pfam:pfam03819 MazG nucleotide pyrophosphohydrolase domain.
 
 
 0.986
rlmD
23S rRNA (uracil(1939)-C(5))-methyltransferase RlmD; Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. RlmD subfamily.
 
     0.924
ALO43398.1
Bifunctional: (P)ppGpp synthetase II guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.
  
  
 
0.915
ndk
Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family.
    
 0.911
ALO41002.1
Exopolyphosphatase; Pfam:pfam02541 Ppx/GppA phosphatase family; Belongs to the GppA/Ppx family.
  
 
 0.909
gppA
Guanosine pentaphosphate phosphohydrolase; Catalyzes the conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the 'stringent response', an adaptive process that allows bacteria to respond to amino acid starvation, resulting in the coordinated regulation of numerous cellular activities.
  
 
 0.909
ALO42165.1
Pfam:pfam00224 Pyruvate kinase, barrel domain; Belongs to the pyruvate kinase family.
   
 
 0.901
ALO41703.1
Adenylate cyclase, family 3 (Some proteins containing HAMP domain); Pfam:pfam00211 Adenylate and Guanylate cyclase catalytic domain.
     
  0.900
ALO42156.1
Adenylate cyclase, family 3; Pfam:pfam05226 CHASE2 domain.
     
  0.900
rpsF
30S ribosomal protein S6; Binds together with S18 to 16S ribosomal RNA.
  
 
 0.843
Your Current Organism:
Pseudoalteromonas phenolica
NCBI taxonomy Id: 161398
Other names: IAM 14989, JCM 21460, KCTC 12086, P. phenolica, Pseudoalteromonas phenolica Isnansetyo and Kamei 2003, Pseudoalteromonas sp. O-BC30, strain O-BC30
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